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Growth hormone regulates nucleolar organizer regions during odontogenesis in the rat.

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  • Additional Information
    • Author-Supplied Keywords:
      growth hormone
      Microdensitometry
      nucleolar organizer regions
      odontogenesis
      transcription
    • Abstract:
      Nucleolar organizers are major sites of ribosomal RNA synthesis and provide an index of transcriptional activity. In order to further define growth hormone actions on nucleolar organizer regions in tooth forming cells, hypophysectomized rats treated with growth hormone for 4 and 24 h, hypophysectomized and sham-operated animals were used. After demineralization and standard paraffin embedding, longitudinal sections of maxillary incisors were stained by a silver stain technique to reveal nucleolar organizer regions. The area of these regions per nucleus was measured using a modified microdensitometer. Analyses of variance of the resulting data showed that preameloblasts and preodontoblasts have greater silver stained nucleolar organizer region values than ameloblasts and odontoblasts. Hypophysectomy reduced and growth hormone partly restored the level of nucleolar organizer regions in preameloblasts and preodontoblasts, but not in mature ameloblasts or odontoblasts. In the case of the younger preameloblasts and preodontoblasts, the effect of growth hormone was seen within 4 h of growth hormone injection. In conclusion, rRNA synthesis, as revealed by the specific silver staining of nucleolar organizer regions in tooth forming cells, appears to be regulated by growth hormone over a relatively short time frame. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Oral Pathology & Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Faculty of Dentistry, University of Queensland, Australia
      2Department of Physiology & Pharmacology, University of Queensland, Australia
    • ISSN:
      0904-2512
    • Accession Number:
      10.1111/j.1600-0714.1992.tb01026.x
    • Accession Number:
      11476511
  • Citations
    • ABNT:
      ZHANG, C. Z. et al. Growth hormone regulates nucleolar organizer regions during odontogenesis in the rat. Journal of Oral Pathology & Medicine, [s. l.], v. 21, n. 9, p. 395–400, 1992. DOI 10.1111/j.1600-0714.1992.tb01026.x. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=11476511. Acesso em: 20 set. 2020.
    • AMA:
      Zhang CZ, Young WG, Li H, Rolinson S, Waters MJ. Growth hormone regulates nucleolar organizer regions during odontogenesis in the rat. Journal of Oral Pathology & Medicine. 1992;21(9):395-400. doi:10.1111/j.1600-0714.1992.tb01026.x
    • APA:
      Zhang, C. Z., Young, W. G., Li, H., Rolinson, S., & Waters, M. J. (1992). Growth hormone regulates nucleolar organizer regions during odontogenesis in the rat. Journal of Oral Pathology & Medicine, 21(9), 395–400. https://doi.org/10.1111/j.1600-0714.1992.tb01026.x
    • Chicago/Turabian: Author-Date:
      Zhang, C.Z., W.G. Young, H. Li, S. Rolinson, and M.J. Waters. 1992. “Growth Hormone Regulates Nucleolar Organizer Regions during Odontogenesis in the Rat.” Journal of Oral Pathology & Medicine 21 (9): 395–400. doi:10.1111/j.1600-0714.1992.tb01026.x.
    • Harvard:
      Zhang, C. Z. et al. (1992) ‘Growth hormone regulates nucleolar organizer regions during odontogenesis in the rat’, Journal of Oral Pathology & Medicine, 21(9), pp. 395–400. doi: 10.1111/j.1600-0714.1992.tb01026.x.
    • Harvard: Australian:
      Zhang, CZ, Young, WG, Li, H, Rolinson, S & Waters, MJ 1992, ‘Growth hormone regulates nucleolar organizer regions during odontogenesis in the rat’, Journal of Oral Pathology & Medicine, vol. 21, no. 9, pp. 395–400, viewed 20 September 2020, .
    • MLA:
      Zhang, C. Z., et al. “Growth Hormone Regulates Nucleolar Organizer Regions during Odontogenesis in the Rat.” Journal of Oral Pathology & Medicine, vol. 21, no. 9, Oct. 1992, pp. 395–400. EBSCOhost, doi:10.1111/j.1600-0714.1992.tb01026.x.
    • Chicago/Turabian: Humanities:
      Zhang, C.Z., W.G. Young, H. Li, S. Rolinson, and M.J. Waters. “Growth Hormone Regulates Nucleolar Organizer Regions during Odontogenesis in the Rat.” Journal of Oral Pathology & Medicine 21, no. 9 (October 1992): 395–400. doi:10.1111/j.1600-0714.1992.tb01026.x.
    • Vancouver/ICMJE:
      Zhang CZ, Young WG, Li H, Rolinson S, Waters MJ. Growth hormone regulates nucleolar organizer regions during odontogenesis in the rat. Journal of Oral Pathology & Medicine [Internet]. 1992 Oct [cited 2020 Sep 20];21(9):395–400. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=a9h&AN=11476511