Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Incorporation of log odds of positive lymph nodes into the AJCC TNM classification improves prediction of survival in oral cancer.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Abstract:
      Objectives To assess the prognostic performance of a new N classification that incorporates the log odds of positive lymph nodes ( LODDS) into the routinely used pathological N classification for oral squamous cell carcinoma ( OSCC) patients. Design Retrospective cohort study utilising LODDS into pN category was performed, and the AJCC TNM stage and T-New N-M stage were compared with respect to 5-year disease-specific survival ( DSS) rates. The discriminability was evaluated from the linear trend chi-square test, Akaike information criterion ( AIC) and Harrell's c-statistic. Setting Medical centrer in Taiwan. Participants A total of 463 patients received primary surgery and neck dissection between 2004 and 2013 for OSCC. Main outcome measures The discriminability for 5-year DSS rates. Results The median follow-up period was 54 months, the mean patient age was 54 ± 11 years and 428 patients (92.4%) were male. The patients with higher LODDS had worse 5-year DSS rates. Incorporation of LODDS into the prognostic model based on the seventh edition of the TNM classification significantly improved discriminative performance for 5-year DSS with a lower AIC (1883 versus 1897), and higher prediction accuracy (Harrell's c-statistic: 0.768 versus 0.764). Conclusions By utilising a merger of the LODDS and pN classifications to create a new N classification has better discriminatory and predictive ability than pathological TNM staging and could help identify high-risk patients for intense adjuvant therapy. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Clinical Otolaryngology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)