Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      minor stroke
      oxidative lipoprotein
      oxidized low‐density lipoprotein
      prognosis
      transient ischaemic attack
    • Abstract:
      Background and purpose: Oxidative stress plays an important role in acute ischaemic stroke. However, the association of oxidative lipoprotein markers, including oxidized low‐density lipoprotein (oxLDL), oxLDL:high‐density lipoprotein (HDL) and oxLDL:low‐density lipoprotein (LDL), with functional outcome of minor stroke or transient ischaemic attack (TIA) remains unclear. We aimed to investigate the association between oxidative lipoprotein markers and poor functional outcome in patients with minor stroke or TIA. Methods: All patients with minor stroke or TIA were recruited from the Clopidogrel in High‐Risk Patients With Acute Non‐Disabling Cerebrovascular Events (CHANCE) trial. The poor functional outcome included modified Rankin Scale (mRS) score 2–6 and 3–6 at 90‐day and 12‐month follow‐up. Multivariate logistic regression was used to investigate the associations of oxLDL, oxLDL:HDL and oxLDL:LDL with poor functional outcome. Results: Among 3019 patients included in this study, the median (interquartile range) oxLDL, oxLDL:HDL and oxLDL:LDL were 13.96 (6.65–28.81), 4.52 (2.08–9.32) and 11.73 (5.27–24.85) μg/dL, respectively. After adjusted for confounding factors, patients in the highest oxLDL quartile had a higher proportion of mRS score 2–6 at 90 days [hazard ratio (HR), 1.78; 95% confidence interval (CI), 1.26–2.52] and 12 months (HR, 1.42; 95% CI, 1.01–1.99), and mRS score 3–6 at 90 days (HR, 1.98; 95% CI, 1.29–3.04) and 12 months (HR, 1.77; 95% CI, 1.09–2.89) when compared with the lowest oxLDL quartile (P < 0.05). Similar results were found for oxLDL:HDL and oxLDL:LDL. Conclusions: Higher levels of oxidative lipoprotein markers are independent predictors of poor functional outcome in patients with minor stroke or TIA at 90 days and 12 months. [ABSTRACT FROM AUTHOR]
    • :
      Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      1351-5101
    • DOI:
      10.1111/ene.13943
    • Accession Number:
      137375011
  • Citations
    • ABNT:
      WANG, A. et al. Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack. European Journal of Neurology, [s. l.], v. 26, n. 8, p. 1082–1090, 2019. DOI 10.1111/ene.13943. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=137375011. Acesso em: 26 set. 2020.
    • AMA:
      Wang A, Zhang X, Li S, et al. Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack. European Journal of Neurology. 2019;26(8):1082-1090. doi:10.1111/ene.13943
    • APA:
      Wang, A., Zhang, X., Li, S., Zhao, X., Liu, L., Johnston, S. C., Meng, X., Lin, J., Zuo, Y., Li, H., & Wang, Y. (2019). Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack. European Journal of Neurology, 26(8), 1082–1090. https://doi.org/10.1111/ene.13943
    • Chicago/Turabian: Author-Date:
      Wang, A., X. Zhang, S. Li, X. Zhao, L. Liu, S. C. Johnston, X. Meng, et al. 2019. “Oxidative Lipoprotein Markers Predict Poor Functional Outcome in Patients with Minor Stroke or Transient Ischaemic Attack.” European Journal of Neurology 26 (8): 1082–90. doi:10.1111/ene.13943.
    • Harvard:
      Wang, A. et al. (2019) ‘Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack’, European Journal of Neurology, 26(8), pp. 1082–1090. doi: 10.1111/ene.13943.
    • Harvard: Australian:
      Wang, A, Zhang, X, Li, S, Zhao, X, Liu, L, Johnston, SC, Meng, X, Lin, J, Zuo, Y, Li, H & Wang, Y 2019, ‘Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack’, European Journal of Neurology, vol. 26, no. 8, pp. 1082–1090, viewed 26 September 2020, .
    • MLA:
      Wang, A., et al. “Oxidative Lipoprotein Markers Predict Poor Functional Outcome in Patients with Minor Stroke or Transient Ischaemic Attack.” European Journal of Neurology, vol. 26, no. 8, Aug. 2019, pp. 1082–1090. EBSCOhost, doi:10.1111/ene.13943.
    • Chicago/Turabian: Humanities:
      Wang, A., X. Zhang, S. Li, X. Zhao, L. Liu, S. C. Johnston, X. Meng, et al. “Oxidative Lipoprotein Markers Predict Poor Functional Outcome in Patients with Minor Stroke or Transient Ischaemic Attack.” European Journal of Neurology 26, no. 8 (August 2019): 1082–90. doi:10.1111/ene.13943.
    • Vancouver/ICMJE:
      Wang A, Zhang X, Li S, Zhao X, Liu L, Johnston SC, et al. Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack. European Journal of Neurology [Internet]. 2019 Aug [cited 2020 Sep 26];26(8):1082–90. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=137375011