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Safety and efficacy of taurine as an add‐on treatment for tics in youngsters.

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  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      taurine
      tiapride
      tic disorders
      treatment outcome
    • Abstract:
      Background and purpose: The pathophysiological model of tics generally describes disruption of γ‐aminobutyric acid transmission, and taurine is found to be an agonist of γ‐aminobutyric acid receptors. The study aimed to evaluate the safety and efficacy of taurine as an add‐on treatment for tics. Methods: Four hundred and four youngsters with tic disorders were randomly assigned to 12 weeks of either oral taurine or placebo. The Yale Global Tic Severity Scale was used to measure tic severity. The primary outcome measure was global severity scores reduced by more than 60% compared with baseline scores. Results: Three hundred and eighty‐two patients were successfully treated. At week 4, no significant differences were found in the treatment effect and the total occurrence of adverse drug reactions between the taurine and placebo groups. At week 12, the proportion of significant improvement in tics was significantly higher in the taurine group than the placebo group (53.4% with taurine versus 34.5% without taurine; relative risk 1.546; P < 0.001), and no group differences were found in the total occurrence of adverse drug reactions. Conclusions: Taurine is safe and effective for tics. [ABSTRACT FROM AUTHOR]
    • :
      Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Full Text Word Count:
      5548
    • ISSN:
      1351-5101
    • DOI:
      10.1111/ene.14107
    • Accession Number:
      141629224
  • Citations
    • ABNT:
      DING, L. et al. Safety and efficacy of taurine as an add‐on treatment for tics in youngsters. European Journal of Neurology, [s. l.], v. 27, n. 3, p. 490–497, 2020. DOI 10.1111/ene.14107. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=141629224. Acesso em: 24 set. 2020.
    • AMA:
      Ding L, Yang Z, Liu G, et al. Safety and efficacy of taurine as an add‐on treatment for tics in youngsters. European Journal of Neurology. 2020;27(3):490-497. doi:10.1111/ene.14107
    • APA:
      Ding, L., Yang, Z., Liu, G., Ran, N., Yi, M., Li, H., Zhao, H., Tang, L., Cheng, H., Zhao, J., Zhang, Y., Ji, X., & Liu, S. (2020). Safety and efficacy of taurine as an add‐on treatment for tics in youngsters. European Journal of Neurology, 27(3), 490–497. https://doi.org/10.1111/ene.14107
    • Chicago/Turabian: Author-Date:
      Ding, L., Z. Yang, G. Liu, N. Ran, M. Yi, H. Li, H. Zhao, et al. 2020. “Safety and Efficacy of Taurine as an Add‐on Treatment for Tics in Youngsters.” European Journal of Neurology 27 (3): 490–97. doi:10.1111/ene.14107.
    • Harvard:
      Ding, L. et al. (2020) ‘Safety and efficacy of taurine as an add‐on treatment for tics in youngsters’, European Journal of Neurology, 27(3), pp. 490–497. doi: 10.1111/ene.14107.
    • Harvard: Australian:
      Ding, L, Yang, Z, Liu, G, Ran, N, Yi, M, Li, H, Zhao, H, Tang, L, Cheng, H, Zhao, J, Zhang, Y, Ji, X & Liu, S 2020, ‘Safety and efficacy of taurine as an add‐on treatment for tics in youngsters’, European Journal of Neurology, vol. 27, no. 3, pp. 490–497, viewed 24 September 2020, .
    • MLA:
      Ding, L., et al. “Safety and Efficacy of Taurine as an Add‐on Treatment for Tics in Youngsters.” European Journal of Neurology, vol. 27, no. 3, Mar. 2020, pp. 490–497. EBSCOhost, doi:10.1111/ene.14107.
    • Chicago/Turabian: Humanities:
      Ding, L., Z. Yang, G. Liu, N. Ran, M. Yi, H. Li, H. Zhao, et al. “Safety and Efficacy of Taurine as an Add‐on Treatment for Tics in Youngsters.” European Journal of Neurology 27, no. 3 (March 2020): 490–97. doi:10.1111/ene.14107.
    • Vancouver/ICMJE:
      Ding L, Yang Z, Liu G, Ran N, Yi M, Li H, et al. Safety and efficacy of taurine as an add‐on treatment for tics in youngsters. European Journal of Neurology [Internet]. 2020 Mar [cited 2020 Sep 24];27(3):490–7. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=141629224