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Setting the stage for functional repair of spinal cord injuries: a cast of thousands.

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  • Additional Information
    • Subject Terms:
    • Author-Supplied Keywords:
      neuroprotection
      plasticity
      regeneration
      rehabilitation
      spinal cord injury
      transplantation
    • Abstract:
      Here we review mechanisms and molecules that necessitate protection and oppose axonal growth in the injured spinal cord, representing not only a cast of villains but also a company of therapeutic targets, many of which have yet to be fully exploited. We next discuss recent progress in the fields of bridging, overcoming conduction block and rehabilitation after spinal cord injury (SCI), where several treatments in each category have entered the spotlight, and some are being tested clinically. Finally, studies that combine treatments targeting different aspects of SCI are reviewed. Although experiments applying some treatments in combination have been completed, auditions for each part in the much-sought combination therapy are ongoing, and performers must demonstrate robust anatomical regeneration and/or significant return of function in animal models before being considered for a lead role.Spinal Cord (2005) 43, 134-161. doi:10.1038/sj.sc.3101715 Published online 25 January 2005 [ABSTRACT FROM AUTHOR]
    • :
      Copyright of Spinal Cord is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      1362-4393
    • DOI:
      10.1038/sj.sc.3101715
    • Accession Number:
      16812329
  • Citations
    • ABNT:
      RAMER, L. M.; RAMER, M. S.; STEEVES, J. D. Setting the stage for functional repair of spinal cord injuries: a cast of thousands. Spinal Cord, [s. l.], v. 43, n. 3, p. 134–161, 2005. DOI 10.1038/sj.sc.3101715. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=16812329. Acesso em: 4 dez. 2020.
    • AMA:
      Ramer LM, Ramer MS, Steeves JD. Setting the stage for functional repair of spinal cord injuries: a cast of thousands. Spinal Cord. 2005;43(3):134-161. doi:10.1038/sj.sc.3101715
    • APA:
      Ramer, L. M., Ramer, M. S., & Steeves, J. D. (2005). Setting the stage for functional repair of spinal cord injuries: a cast of thousands. Spinal Cord, 43(3), 134–161. https://doi.org/10.1038/sj.sc.3101715
    • Chicago/Turabian: Author-Date:
      Ramer, L. M., M. S. Ramer, and J. D. Steeves. 2005. “Setting the Stage for Functional Repair of Spinal Cord Injuries: A Cast of Thousands.” Spinal Cord 43 (3): 134–61. doi:10.1038/sj.sc.3101715.
    • Harvard:
      Ramer, L. M., Ramer, M. S. and Steeves, J. D. (2005) ‘Setting the stage for functional repair of spinal cord injuries: a cast of thousands’, Spinal Cord, 43(3), pp. 134–161. doi: 10.1038/sj.sc.3101715.
    • Harvard: Australian:
      Ramer, LM, Ramer, MS & Steeves, JD 2005, ‘Setting the stage for functional repair of spinal cord injuries: a cast of thousands’, Spinal Cord, vol. 43, no. 3, pp. 134–161, viewed 4 December 2020, .
    • MLA:
      Ramer, L. M., et al. “Setting the Stage for Functional Repair of Spinal Cord Injuries: A Cast of Thousands.” Spinal Cord, vol. 43, no. 3, Mar. 2005, pp. 134–161. EBSCOhost, doi:10.1038/sj.sc.3101715.
    • Chicago/Turabian: Humanities:
      Ramer, L. M., M. S. Ramer, and J. D. Steeves. “Setting the Stage for Functional Repair of Spinal Cord Injuries: A Cast of Thousands.” Spinal Cord 43, no. 3 (March 2005): 134–61. doi:10.1038/sj.sc.3101715.
    • Vancouver/ICMJE:
      Ramer LM, Ramer MS, Steeves JD. Setting the stage for functional repair of spinal cord injuries: a cast of thousands. Spinal Cord [Internet]. 2005 Mar [cited 2020 Dec 4];43(3):134–61. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=c9h&AN=16812329