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Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging.

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  • Author(s): Li, H.; Hao, L.; Li, Y.; Wang, Rong
  • Source:
    Journal of Nutrition, Health & Aging (J NUTR HEALTH AGING), Jul2018; 22(7): 785-789. (5p)
  • Publication Type:
    Article - pictorial, research, tables/charts
  • Language:
    English
  • Additional Information
    • Affiliation:
      Central Laboratory, Department of General Surgery, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China
      Department of Liver Cancer Center, Beijing 302 Hospital, Beijing, China
      Nursing Department, Beijing 302 Hospital, Beijing, China
      Central Laboratory, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background: Alzheimer’s disease (AD) is one of the most common and devastating aging related neurodegenerative diseases. Aging is a natural physiological process, a progressive deterioration of the overall homeostatic brain mechanisms, accompanied by cognitive decline. CXCL12/CXCR4 chemokine signaling plays a critical role in modulating various nervous system developmental processes and in regulating synaptic plasticity.Results: In this article, we have firstly shown that CXCR4 is critical for cell proliferation and cytotoxicity in the SH-SY5Y cell model. Moreover, it has been firstly demonstrated that CXCR4 colocalized with AKT on the membrane and regulated the AKT activation to prevent aging and AD.Discussion: In a word, we supply a novel pathway that CXCR4 pathway stimulated by CXCL12 regulated AKT activation, CREB phosphorylation and P53 level to affect the process of aging and AD. Therefore, CXCR4 may be a novel target and biomarker for the diagnosis and treatment of AD and aging.
    • Journal Subset:
      Allied Health; Biomedical; Continental Europe; Europe; Peer Reviewed
    • ISSN:
      1279-7707
    • MEDLINE Info:
      NLM UID: 100893366
    • Publication Date:
      20180724
    • Publication Date:
      20190701
    • Accession Number:
      http://dx.doi.org/10.1007/s12603-018-1013-9
    • Accession Number:
      130795786
  • Citations
    • ABNT:
      LI, H. et al. Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. Journal of Nutrition, Health & Aging, [s. l.], v. 22, n. 7, p. 785–789, 2018. DOI 10.1007/s12603-018-1013-9. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ccm&AN=130795786. Acesso em: 15 ago. 2020.
    • AMA:
      Li H, Hao L, Li Y, Wang R. Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. Journal of Nutrition, Health & Aging. 2018;22(7):785-789. doi:10.1007/s12603-018-1013-9
    • APA:
      Li, H., Hao, L., Li, Y., & Wang, R. (2018). Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. Journal of Nutrition, Health & Aging, 22(7), 785–789. https://doi.org/10.1007/s12603-018-1013-9
    • Chicago/Turabian: Author-Date:
      Li, H., L. Hao, Y. Li, and Rong Wang. 2018. “Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging.” Journal of Nutrition, Health & Aging 22 (7): 785–89. doi:10.1007/s12603-018-1013-9.
    • Harvard:
      Li, H. et al. (2018) ‘Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging’, Journal of Nutrition, Health & Aging, 22(7), pp. 785–789. doi: 10.1007/s12603-018-1013-9.
    • Harvard: Australian:
      Li, H, Hao, L, Li, Y & Wang, R 2018, ‘Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging’, Journal of Nutrition, Health & Aging, vol. 22, no. 7, pp. 785–789, viewed 15 August 2020, .
    • MLA:
      Li, H., et al. “Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging.” Journal of Nutrition, Health & Aging, vol. 22, no. 7, July 2018, pp. 785–789. EBSCOhost, doi:10.1007/s12603-018-1013-9.
    • Chicago/Turabian: Humanities:
      Li, H., L. Hao, Y. Li, and Rong Wang. “Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging.” Journal of Nutrition, Health & Aging 22, no. 7 (July 2018): 785–89. doi:10.1007/s12603-018-1013-9.
    • Vancouver/ICMJE:
      Li H, Hao L, Li Y, Wang R. Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. Journal of Nutrition, Health & Aging [Internet]. 2018 Jul [cited 2020 Aug 15];22(7):785–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ccm&AN=130795786