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Safety and efficacy of taurine as an add-on treatment for tics in youngsters

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  • Source:
    European journal of neurology 2019
  • Additional Information
    • Author(s):
      Ding L, Yang Z, Liu G, Ran N, Yi M, Li H, Zhao H, Tang L, Cheng H, Zhao J, Zhang Y, Ji X, Liu S
    • Contact Information:
      Department of Epidemiology and Health Statistics, The Affiliated Hospital of Qingdao University, China
    • Language:
      English
    • Publication Type:
      Journal: Article in Press
    • Record Status:
      This record is this issue.
    • Abstract:
      Background and purpose: The pathophysiological model of tics generally describes disruption of γ-aminobutyric acid transmission, and taurine is found to be an agonist of γ-aminobutyric acid receptors. The study aimed to evaluate the safety and efficacy of taurine as an add-on treatment for tics. Methods: Four hundred and four youngsters with tic disorders were randomly assigned to 12 weeks of either oral taurine or placebo. The Yale Global Tic Severity Scale was used to measure tic severity. The primary outcome measure was global severity scores reduced by more than 60% compared with baseline scores. Results: Three hundred and eighty-two patients were successfully treated. At week 4, no significant differences were found in the treatment effect and the total occurrence of adverse drug reactions between the taurine and placebo groups. At week 12, the proportion of significant improvement in tics was significantly higher in the taurine group than the placebo group (53.4% with taurine versus 34.5% without taurine; relative risk 1.546; PÂ
    • EMBASE keywords:
      adult; adverse drug reaction; article; *drug efficacy; *drug safety; drug therapy; female; human; major clinical study; male; pharmacokinetics; randomized controlled trial; risk factor; side effect; *tic
    • Accession Number:
      2003607143
    • Source:
      This document should be cited as: Ding L Yang Z Liu G Ran N Yi M Li H Zhao H Tang L Cheng H Zhao J Zhang Y Ji X Liu S. Safety and efficacy of taurine as an add-on treatment for tics in youngsters 2019 (The Cochrane Controlled Trials Register (CCTR/CENTRAL). DOI: 10.1111/ene.14107. Oxford: Update Software. Updated quarterly.
    • Accession Number:
      CN-02006185
  • Citations
    • ABNT:
      DING L et al. Safety and efficacy of taurine as an add-on treatment for tics in youngsters. European journal of neurology, [s. l.], 2019. DOI 10.1111/ene.14107. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cgh&AN=CN-02006185. Acesso em: 26 out. 2020.
    • AMA:
      Ding L, Yang Z, Liu G, et al. Safety and efficacy of taurine as an add-on treatment for tics in youngsters. European journal of neurology. January 2019. doi:10.1111/ene.14107
    • APA:
      Ding L, Yang Z, Liu G, Ran N, Yi M, Li H, Zhao H, Tang L, Cheng H, Zhao J, Zhang Y, Ji X, & Liu S. (2019). Safety and efficacy of taurine as an add-on treatment for tics in youngsters. European Journal of Neurology. https://doi.org/10.1111/ene.14107
    • Chicago/Turabian: Author-Date:
      Ding L, Yang Z, Liu G, Ran N, Yi M, Li H, Zhao H, et al. 2019. “Safety and Efficacy of Taurine as an Add-on Treatment for Tics in Youngsters.” European Journal of Neurology, January. doi:10.1111/ene.14107.
    • Harvard:
      Ding L et al. (2019) ‘Safety and efficacy of taurine as an add-on treatment for tics in youngsters’, European journal of neurology. doi: 10.1111/ene.14107.
    • Harvard: Australian:
      Ding L, Yang Z, Liu G, Ran N, Yi M, Li H, Zhao H, Tang L, Cheng H, Zhao J, Zhang Y, Ji X & Liu S 2019, ‘Safety and efficacy of taurine as an add-on treatment for tics in youngsters’, European journal of neurology, viewed 26 October 2020, .
    • MLA:
      Ding L, et al. “Safety and Efficacy of Taurine as an Add-on Treatment for Tics in Youngsters.” European Journal of Neurology, Jan. 2019. EBSCOhost, doi:10.1111/ene.14107.
    • Chicago/Turabian: Humanities:
      Ding L, Yang Z, Liu G, Ran N, Yi M, Li H, Zhao H, et al. “Safety and Efficacy of Taurine as an Add-on Treatment for Tics in Youngsters.” European Journal of Neurology, January 1, 2019. doi:10.1111/ene.14107.
    • Vancouver/ICMJE:
      Ding L, Yang Z, Liu G, Ran N, Yi M, Li H, et al. Safety and efficacy of taurine as an add-on treatment for tics in youngsters. European journal of neurology [Internet]. 2019 Jan 1 [cited 2020 Oct 26]; Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cgh&AN=CN-02006185