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Safety and efficacy of taurine as an add-on treatment for tics in the youngsters

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  • Source:
    European journal of neurology 2019
  • Additional Information
    • Original Title:
      Safety and efficacy of taurine as an add-on treatment for tics in the youngsters
    • Language:
      English
    • Publication Type:
      Journal: Article in Press
    • Record Status:
      This record is this issue.
    • Abstract:
      BACKGROUND: The pathophysiological model of tics generally describes disruption of γ-aminobutyric acid transmission, and taurine is found to be an agonist of γ-aminobutyric acid receptors. METHODS: 404 youngsters with tic disorders were randomly assigned to 12 weeks of either oral taurine or placebo. The Yale Global Tic Severity Scale was used to measure tic severity. The primary outcome measure was global severity scores reduced by more than 60% compared with baseline scores. RESULTS: 382 patients were successfully treated. At week 4, no significant differences were found in the treatment effect and total occurrence of adverse drug reactions between the taurine and placebo groups. At week 12, the proportion of significant improvement in tics was significantly higher in the taurine group than the placebo group (53.4% with taurine versus 34.5% without taurine; Relative Risk = 1.546; P
    • EMBASE keywords:
      adult; adverse drug reaction; article; controlled study; *drug efficacy; *drug safety; drug therapy; female; human; major clinical study; male; pharmacokinetics; risk factor; side effect; *tic
    • Accession Number:
      629620139
    • Source:
      This document should be cited as: . Safety and efficacy of taurine as an add-on treatment for tics in the youngsters 2019 (The Cochrane Controlled Trials Register (CCTR/CENTRAL). DOI: 10.1111/ene.14107. Oxford: Update Software. Updated quarterly.
    • Accession Number:
      CN-02011467
  • Citations
    • ABNT:
      Safety and efficacy of taurine as an add-on treatment for tics in the youngsters. European journal of neurology, [s. l.], 2019. DOI 10.1111/ene.14107. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cgh&AN=CN-02011467. Acesso em: 26 out. 2020.
    • AMA:
      Safety and efficacy of taurine as an add-on treatment for tics in the youngsters. European journal of neurology. January 2019. doi:10.1111/ene.14107
    • APA:
      Safety and efficacy of taurine as an add-on treatment for tics in the youngsters. (2019). European Journal of Neurology. https://doi.org/10.1111/ene.14107
    • Chicago/Turabian: Author-Date:
      “Safety and Efficacy of Taurine as an Add-on Treatment for Tics in the Youngsters.” 2019. European Journal of Neurology, January. doi:10.1111/ene.14107.
    • Harvard:
      ‘Safety and efficacy of taurine as an add-on treatment for tics in the youngsters’ (2019) European journal of neurology. doi: 10.1111/ene.14107.
    • Harvard: Australian:
      ‘Safety and efficacy of taurine as an add-on treatment for tics in the youngsters’ 2019, European journal of neurology, viewed 26 October 2020, .
    • MLA:
      “Safety and Efficacy of Taurine as an Add-on Treatment for Tics in the Youngsters.” European Journal of Neurology, Jan. 2019. EBSCOhost, doi:10.1111/ene.14107.
    • Chicago/Turabian: Humanities:
      “Safety and Efficacy of Taurine as an Add-on Treatment for Tics in the Youngsters.” European Journal of Neurology, January 1, 2019. doi:10.1111/ene.14107.
    • Vancouver/ICMJE:
      Safety and efficacy of taurine as an add-on treatment for tics in the youngsters. European journal of neurology [Internet]. 2019 Jan 1 [cited 2020 Oct 26]; Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cgh&AN=CN-02011467