Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Source:
    Journal of medical virology 2019 91 8, 1499 (1499-1509)
  • Additional Information
    • Author(s):
      Liu T, Sun Y, Zhou J, Yang F, Zou X, Wang L, Wu X, Chen Y, Piao H, Lu L, Jiang W, Xu Y, Feng B, Nan Y, Xie W, Chen G, Zheng H, Li H, Ding H, Liu H, Wang T, Ou X, Wu S, Kong Y, Wang P, Cong M, Zhang Y, You H, Jia J
    • Language:
      English
    • Publication Type:
      Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
    • Record Status:
      This record is this issue.
    • Abstract:
      Wisteria floribunda agglutinin-positive Mac-2-binding protein (M2BP) has been identified as a predictor for the response of interferon α (IFN-α) in patients with viral hepatitis. However, whether serum glycosylation isomer of M2BP (M2BPGi) was associated with the regression of liver fibrosis in patients with chronic hepatitis B (CHB) during IFN-α add-on therapy is still unknown. CHB patients were treated with entecavir for 26 weeks followed by entecavir plus pegylated IFN-α for 52 weeks. Liver biopsies were taken at baseline and treatment week 78. The regression of fibrosis was identified according to Ishak standard or Ishak plus Progressive-Indeterminate-Regressive (P-I-R) standard. Serum M2BPGi and liver function tests were measured at baseline and every 26 weeks of treatment. A total of 72 CHB patients were included in the present study. Serum M2BPGi was correlated with fibrosis and necroinflammation both at baseline and week 78. If Ishak standard was used as the reference, only the percent change of M2BPGi at week 52 from week 26 (Δ%M2BPGi26w-52W ) was independently associated with fibrosis regression at treatment week 78, the area under the ROC curve (AUROC) of Δ%M2BPGi26w-52W for predicting fibrosis regression was 0.705. As for Ishak plus P-I-R standard, the AUROC of the predictive model for fibrosis regression (0.896*M2BPGi52W  + 0.363*necroinflammation score0w  + 2.051*Ishak score0w  - 4.489) was 0.888. These data indicated that dynamic changes of serum M2BPGi were associated with fibrosis regression in CHB patients on IFN-α add-on therapy.
    • Medical Subject Headings (MeSH):
      Adult
      Aged
      Female
      Humans
      Male
      Middle Aged
      Young Adult
      Adolescent
      Biopsy
      Guanine/administration & dosage
      Histocytochemistry
      Liver/pathology
      ROC Curve
      Treatment Outcome
      Antigens, Neoplasm/*blood
      Antiviral Agents/*administration & dosage
      Biomarkers, Tumor/*blood
      Guanine/*analogs & derivatives
      Hepatitis B, Chronic/*complications
      Hepatitis B, Chronic/*drug therapy
      Interferon-alpha/*administration & dosage
      Liver Cirrhosis/*pathology
    • Source:
      This document should be cited as: Liu T Sun Y Zhou J Yang F Zou X Wang L Wu X Chen Y Piao H Lu L Jiang W Xu Y Feng B Nan Y Xie W Chen G Zheng H Li H Ding H Liu H Wang T Ou X Wu S Kong Y Wang P Cong M Zhang Y You H Jia J. On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy 2019 (The Cochrane Controlled Trials Register (CCTR/CENTRAL). DOI: 10.1002/jmv.25465. Oxford: Update Software. Updated quarterly.
    • Accession Number:
      CN-02124186
  • Citations
    • ABNT:
      LIU T et al. On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy. Journal of medical virology, [s. l.], v. 91, n. 8, p. 1499–1509, 2019. DOI 10.1002/jmv.25465. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cgh&AN=CN-02124186. Acesso em: 1 out. 2020.
    • AMA:
      Liu T, Sun Y, Zhou J, et al. On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy. Journal of medical virology. 2019;91(8):1499-1509. doi:10.1002/jmv.25465
    • APA:
      Liu T, Sun Y, Zhou J, Yang F, Zou X, Wang L, Wu X, Chen Y, Piao H, Lu L, Jiang W, Xu Y, Feng B, Nan Y, Xie W, Chen G, Zheng H, Li H, Ding H, … Jia J. (2019). On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy. Journal of Medical Virology, 91(8), 1499–1509. https://doi.org/10.1002/jmv.25465
    • Chicago/Turabian: Author-Date:
      Liu T, Sun Y, Zhou J, Yang F, Zou X, Wang L, Wu X, et al. 2019. “On-Treatment Changes of Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Are Associated with the Regression of Liver Fibrosis in Chronic Hepatitis B Patients on Interferon α Add-on Therapy.” Journal of Medical Virology 91 (8): 1499–1509. doi:10.1002/jmv.25465.
    • Harvard:
      Liu T et al. (2019) ‘On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy’, Journal of medical virology, 91(8), pp. 1499–1509. doi: 10.1002/jmv.25465.
    • Harvard: Australian:
      Liu T, Sun Y, Zhou J, Yang F, Zou X, Wang L, Wu X, Chen Y, Piao H, Lu L, Jiang W, Xu Y, Feng B, Nan Y, Xie W, Chen G, Zheng H, Li H, Ding H, Liu H, Wang T, Ou X, Wu S, Kong Y, Wang P, Cong M, Zhang Y, You H & Jia J 2019, ‘On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy’, Journal of medical virology, vol. 91, no. 8, pp. 1499–1509, viewed 1 October 2020, .
    • MLA:
      Liu T, et al. “On-Treatment Changes of Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Are Associated with the Regression of Liver Fibrosis in Chronic Hepatitis B Patients on Interferon α Add-on Therapy.” Journal of Medical Virology, vol. 91, no. 8, Jan. 2019, pp. 1499–1509. EBSCOhost, doi:10.1002/jmv.25465.
    • Chicago/Turabian: Humanities:
      Liu T, Sun Y, Zhou J, Yang F, Zou X, Wang L, Wu X, et al. “On-Treatment Changes of Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Are Associated with the Regression of Liver Fibrosis in Chronic Hepatitis B Patients on Interferon α Add-on Therapy.” Journal of Medical Virology 91, no. 8 (January 1, 2019): 1499–1509. doi:10.1002/jmv.25465.
    • Vancouver/ICMJE:
      Liu T, Sun Y, Zhou J, Yang F, Zou X, Wang L, et al. On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon α add-on therapy. Journal of medical virology [Internet]. 2019 Jan 1 [cited 2020 Oct 1];91(8):1499–509. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cgh&AN=CN-02124186