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Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study

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  • Source:
    Neuromodulation 2019 22 7, e403 (e403-) Published by: Blackwell Publishing Inc. Netherlands
  • Additional Information
    • Original Title:
      Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study
    • Contact Information:
      Erasmus University Rotterdam, Department of Psychology- Education and Child studies, Netherlands
    • Language:
      English
    • Publication Type:
      Journal: Conference Abstract
    • Record Status:
      This record is this issue.
    • Abstract:
      Introduction: Repeated transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been shown to decrease craving in various substance use disorders, and seemed to reduce relapse rates in alcohol addiction. The few studies that have explored tDCS in cocaine addiction found that tDCS may reduce craving, but little is known about the effects of tDCS on relapse rates. The current study explored whether repeated sessions of tDCS over the DLPFC as add-on treatment could affect relapse to cocaine use for three months. In addition, measures of cognitive control were taken into account to get a better understanding of the working mechanism. Materials/Methods: The current study had a between subject, doubleblind, randomized, sham-controlled design (https://clinicaltrials.gov/ct2/ show/NCT03025321). Recently abstinent cocaine addicted patients were randomly allocated to either active tDCS (n = 29) or sham tDCS (n = 27) two-times daily for five consecutive days. The primary outcome was number of relapse days after three months, as measured by mobile Ecological momentary assessments (EMA) and verified by urine screens. In addition, they kept track of their craving and affect with EMA. Before and after the intervention week, and at three months follow-up participants performed computerised tasks to measure cognitive control. Results: All participants for the current study are included, and data collection for the follow-up stage will be completed in March 2019. It is expected that relapse rates for the active tDCS group will be lower compared to sham tDCS. We expect the effect of tDCS on relapse rates to be modulated by craving and cognitive control. Discussion: A recent study found that repeated tDCS had no effect on relapse in Crack-Cocaine Users (Klauss et al., 2018). If our hypotheses are confirmed, further research is needed to determine the feasibility of tDCS as add-on treatment in cocaine addiction. Conclusions: Conclusions will be drawn after the data collection has been completed. Objectives Future studies need to investigate which modulatory variables can influence the efficacy of repeated tDCS. The use of EMA is recommended to test the efficacy of innovative treatments in addiction research, since it overcomes important issues that are encountered with retrospective selfreports (Jones et al., 2018).
    • EMBASE keywords:
      adult; *cocaine dependence; comparative effectiveness; conference abstract; controlled study; craving; *dorsolateral prefrontal cortex; double blind procedure; drug therapy; *ecological momentary assessment; executive function; experimental therapy; feasibility study; female; follow up; human; human tissue; male; outcome assessment; randomized controlled trial (topic); recurrence risk; *relapse; systematic review; *transcranial direct current stimulation
    • Accession Number:
      631898610
    • Source:
      This document should be cited as: . Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study 2019 (The Cochrane Controlled Trials Register (CCTR/CENTRAL). DOI: 10.1111/ner.12958. Oxford: Update Software. Updated quarterly.
    • Accession Number:
      CN-02147932
  • Citations
    • ABNT:
      Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study. Neuromodulation, [s. l.], v. 22, n. 7, p. e403, 2019. DOI 10.1111/ner.12958. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cgh&AN=CN-02147932. Acesso em: 21 out. 2020.
    • AMA:
      Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study. Neuromodulation. 2019;22(7):e403. doi:10.1111/ner.12958
    • APA:
      Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study. (2019). Neuromodulation, 22(7), e403. https://doi.org/10.1111/ner.12958
    • Chicago/Turabian: Author-Date:
      “Repeated Transcranial Direct Current Stimulation over the Prefrontal Cortex as Add-on Treatment in Cocaine Addiction: An Ecological Momentary Assessment Study.” 2019. Neuromodulation 22 (7): e403. doi:10.1111/ner.12958.
    • Harvard:
      ‘Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study’ (2019) Neuromodulation, 22(7), p. e403. doi: 10.1111/ner.12958.
    • Harvard: Australian:
      ‘Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study’ 2019, Neuromodulation, vol. 22, no. 7, p. e403, viewed 21 October 2020, .
    • MLA:
      “Repeated Transcranial Direct Current Stimulation over the Prefrontal Cortex as Add-on Treatment in Cocaine Addiction: An Ecological Momentary Assessment Study.” Neuromodulation, vol. 22, no. 7, Jan. 2019, p. e403. EBSCOhost, doi:10.1111/ner.12958.
    • Chicago/Turabian: Humanities:
      “Repeated Transcranial Direct Current Stimulation over the Prefrontal Cortex as Add-on Treatment in Cocaine Addiction: An Ecological Momentary Assessment Study.” Neuromodulation 22, no. 7 (January 1, 2019): e403. doi:10.1111/ner.12958.
    • Vancouver/ICMJE:
      Repeated transcranial direct current stimulation over the prefrontal cortex as add-on treatment in cocaine addiction: an ecological momentary assessment study. Neuromodulation [Internet]. 2019 Jan 1 [cited 2020 Oct 21];22(7):e403. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cgh&AN=CN-02147932