Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Publication Year:
      2016
    • Author-Supplied Keywords:
      DSM-5
      fault tree analysis
      NMDA receptor
      psychosis
      reliability engineering
      research domain criteria
      schizophrenia
    • Abstract:
      The grand challenges of schizophrenia research are linking the causes of the disorder to its symptoms and finding ways to overcome those symptoms. We argue that the field will be unable to address these challenges within psychiatry's standard neo-Kraepelinian (DSM) perspective. At the same time the current corrective, based in molecular genetics and cognitive neuroscience, is also likely to flounder due to its neglect for psychiatry's syndromal structure. We suggest adopting a new approach long used in reliability engineering, which also serves as a synthesis of these approaches. This approach, known as fault tree analysis, can be combined with extant neuroscientific data collection and computational modeling efforts to uncover the causal structures underlying the cognitive and affective failures in people with schizophrenia as well as other complex psychiatric phenomena. By making explicit how causes combine from basic faults to downstream failures, this approach makes affordances for: (1) causes that are neither necessary nor sufficient in and of themselves; (2) within-diagnosis heterogeneity; and (3) between diagnosis co-morbidity. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Frontiers in Human Neuroscience is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      16625161
    • Accession Number:
      112326590
  • Citations
    • ABNT:
      MACDONALD III, A. W. et al. Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis. Frontiers in Human Neuroscience, [s. l.], p. 1, 2016. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=112326590. Acesso em: 20 out. 2020.
    • AMA:
      MacDonald III AW, Zick JL, Chafee MV, Netoff TI, Cole MW, Tully LM. Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis. Frontiers in Human Neuroscience. January 2016:1. Accessed October 20, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=112326590
    • APA:
      MacDonald III, A. W., Zick, J. L., Chafee, M. V., Netoff, T. I., Cole, M. W., & Tully, L. M. (2016). Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis. Frontiers in Human Neuroscience, 1.
    • Chicago/Turabian: Author-Date:
      MacDonald III, Angus W., Jennifer L. Zick, Matthew V. Chafee, Theoden I. Netoff, Michael W. Cole, and Laura Magdalen Tully. 2016. “Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis.” Frontiers in Human Neuroscience, January, 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=112326590.
    • Harvard:
      MacDonald III, A. W. et al. (2016) ‘Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis’, Frontiers in Human Neuroscience, p. 1. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=112326590 (Accessed: 20 October 2020).
    • Harvard: Australian:
      MacDonald III, AW, Zick, JL, Chafee, MV, Netoff, TI, Cole, MW & Tully, LM 2016, ‘Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis’, Frontiers in Human Neuroscience, p. 1, viewed 20 October 2020, .
    • MLA:
      MacDonald III, Angus W., et al. “Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis.” Frontiers in Human Neuroscience, Jan. 2016, p. 1. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=112326590.
    • Chicago/Turabian: Humanities:
      MacDonald III, Angus W., Jennifer L. Zick, Matthew V. Chafee, Theoden I. Netoff, Michael W. Cole, and Laura Magdalen Tully. “Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis.” Frontiers in Human Neuroscience, January 6, 2016, 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=112326590.
    • Vancouver/ICMJE:
      MacDonald III AW, Zick JL, Chafee MV, Netoff TI, Cole MW, Tully LM. Integrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis. Frontiers in Human Neuroscience [Internet]. 2016 Jan 6 [cited 2020 Oct 20];1. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=112326590