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Imunomodulatorni ucinak azitromicina. (Bosnian)

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  • Author(s): MARKOTIC, ALEMKA
  • Source:
    Medicus (1330-013X); Oct2018, Vol. 27 Issue 2, p157-164, 8p
  • Additional Information
    • Alternate Title:
      Immunomodulatory Effect of Azithromycin. (English)
    • Abstract:
      Azithromycin is a broad-spectrum antibiotic from a group of macrolide antibiotics that has a strong immunomodulatory eŒect. Relatively few papers focusing on this extremely important property of azithromycin have been published so far. Nevertheless, available literature reveals its enormous potential for immunomodulatory eŒect at the cell and tissue level and in various clinical entities, primarily in the pathology of various acute and chronic respiratory disorders and infections. Accumulating within a whole string of cells, azithromycin uses diŒerent immune mechanisms (epithelial cells, ­broblasts, monocytes/macrophages, dendritic cells, NK cells, T lymphocytes, neutrophils, mast cells, eosinophils) to exert its immunomodulatory eŒect. A limited number of clinical studies indicate the immunomodulatory eŒect of azithromycin in various infections, primarily respiratory infections, as well as in skin and subcutaneous tissue infections, sexually transmitted diseases and gastrointestinal infections and diseases. In most of these studies, conclusions regarding the immunomodulatory eŒect of azithromycin are, in part, based on various calculations supported by in vitro or ex vivo studies. Given its eŒective antimicrobial activity against numerous microorganisms, together with its potent immunomodulatory eŒect, azithromycin is an eŒective therapeutic drug indicated for the treatment of both acute and chronic infections, as well as certain clinical entities and chronic diseases for which no infectious agent has been proven. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Azitromicin je antibiotik široka spektra djelovanja iz skupine makrolidnih antibiotika i ima snažno imunomodulatorno djelovanje. Bez obzira na zasad malen broj radova o ovom iznimno važnom svojstvu azitromicina, iz dostupne se literature lako razaznaje njegov potencijal imunomodulatornog djelovanja na razini stanica i tkiva te u razlicitim klinickim entitetima, ponajprije u patologiji razlicitih akutnih i kronicnih respiratornih poremecaja i infekcija. Azitromicin se nakuplja u nizu stanica i djeluje imunomodulatorno na njih preko razlicitih imunosnih mehanizama (epitelne stanice, ­broblasti, monociti/makrofagi, dendriticke stanice, NK-stanice, T-limfociti, neutro­li, mastociti, eozino­li). Ogranicen broj klinickih studija upucuje na imunomodulatorno djelovanje azitromicina u razlicitim infekcijama, u prvom redu respiratornim, a onda i infekcijama kože i potkožnog tkiva, spolno prenosivim bolestima i infekcijama te bolestima gastrointestinalnog trakta. Vecina njih u svojim se zakljuccima dijelom oslanja na razlicite kalkulacije o imunomodulatornom djelovanju azitromicina, bazirane na studijama in vitro ili ex vivo. Ucinkovito antimikrobno djelovanje azitromicina na brojne mikroorganizme, udruženo s njegovim potentnim imunomodulatornim djelovanjem, cini ovaj lijek snažnim terapeutikom ne samo u akutnim nego i u kronicnim infekcijama, ali i u nekim klinickim entitetima i kronicnim bolestima za koje nije dokazan infektivni uzrocnik. [ABSTRACT FROM AUTHOR]
    • Abstract:
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