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ИНХИБИТОРИ НА АНДРОГЕННИТЕ РЕЦЕПТОРИ ЗА ЛЕЧЕНИЕ НА НЕМЕТАСТАТИЧЕН, РЕЗИСТЕНТЕН НА КАСТРАЦИЯ КАРЦИНОМ НА ПРОСТАТАТА - АНАЛИЗ РАЗХОД/ЕФЕКТИВНОСТ (Bulgarian)

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    • Alternate Title:
      ANDROGEN RECEPTORS INHIBITORS FOR TREATMENT OF NON-METASTATIC, CASTRATION-RESISTANT PROSTATE CANCER - COST-EFFICIENCY ANALYSIS. (English)
    • Abstract:
      The aim of the study was to model local long-term cost-benefit data of alternative health technologies for the treatment of patients with nonmetastatic, castration-resistant prostate cancer (nmCRPC) and to make an indirect comparison based on a network meta-analysis. Input data into the model were the measured and evaluated clinical endpoints in the randomized SPARTAN and PROSPER clinical trials. Indirect comparison is possible due to the presence of a common therapeutic alternative in the control groups of the trials. A Markov model was used with two health states and one absorbing state. The time horizon of the model was lifetime. Costs and benefits were discounted by 3.5% per annum. The chosen perspective was the point of view of the third party payer. The modeling was performed using the TreeAge Pro Health Care software product. The results suggest that apalutamide in combination with androgen-suppressing therapy is a therapeutically effective and cost-effective treatment compared to enzalutamide and androgen-suppressing therapy in patients with non-metastatic, castration-resistant prostate cancer. A probabilistic sensitivity analysis revealed a 75% probability that the value of the cost-benefit ratio would be below the cost-effectiveness threshold of three times the gross domestic product per capita in Bulgaria for previous year. [ABSTRACT FROM AUTHOR]
    • Abstract:
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