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Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics.

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  • Additional Information
    • Publication Year:
      1998
    • Abstract:
      Background: This study evaluated the dose-related ethanol-like subjective effects of the N -methyl-D-aspartate (NMDA) glutamate receptor antagonist ketamine hydrochloride in recently detoxified alcoholics. Methods: Twenty male inpatients meeting DSM-III-R criteria for alcohol dependence and who had not consumed alcohol for 10 to 27 days prior to the study completed 3 test days that involved the intravenous infusion of ketamine hydrochloride (0.1 mg/kg or 0.5 mg/kg) or saline solution under randomized double-blind conditions. Ethanol-like subjective effects were assessed using the Sensation Scale; the Biphasic Alcohol Effects Scale; visual analog scales to measure "high" and degree of similarity to ethanol, cocaine, and marijuana; a scale assessing the number of standard alcohol drinks producing similar subjective effects; and visual analog scales measuring ethanol craving. Results: Ketamine produced dose-related ethanol-like effects on each scale measuring its similarity to ethanol. Its effects were more similar to the sedative or descending limb effects of ethanol than to the stimulant or ascending limb effects. Ketamine effects also were more like ethanol than marijuana or cocaine. Ethanol-like effects were more prominent at the higher ketamine dose, a dose rated as similar to greater levels of ethanol intoxication. However, ketamine did not increase craving for ethanol. Conclusion: The production of ethanol-like subjective effects by ketamine supports the potential clinical importance of NMDA receptor antagonism among the mechanisms underlying the subjective effects of ethanol in humans. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Archives of General Psychiatry is the property of American Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      0003990X
    • Accession Number:
      6020447
  • Citations
    • ABNT:
      KRYSTAL, J. H. et al. Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics. Archives of General Psychiatry, [s. l.], v. 55, n. 4, p. 354, 1998. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=6020447. Acesso em: 26 set. 2020.
    • AMA:
      Krystal JH, Petrakis IL, Webb E, et al. Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics. Archives of General Psychiatry. 1998;55(4):354. Accessed September 26, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=6020447
    • APA:
      Krystal, J. H., Petrakis, I. L., Webb, E., Cooney, N. L., Karper, L. P., Namanworth, S., Stetson, P., Trevisan, L. A., & Charney, D. S. (1998). Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics. Archives of General Psychiatry, 55(4), 354.
    • Chicago/Turabian: Author-Date:
      Krystal, John H., Ismene L. Petrakis, Elizabeth Webb, Ned L. Cooney, Laurence P. Karper, Sheila Namanworth, Philip Stetson, Louis A. Trevisan, and Dennis S. Charney. 1998. “Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics.” Archives of General Psychiatry 55 (4): 354. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=6020447.
    • Harvard:
      Krystal, J. H. et al. (1998) ‘Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics’, Archives of General Psychiatry, 55(4), p. 354. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=6020447 (Accessed: 26 September 2020).
    • Harvard: Australian:
      Krystal, JH, Petrakis, IL, Webb, E, Cooney, NL, Karper, LP, Namanworth, S, Stetson, P, Trevisan, LA & Charney, DS 1998, ‘Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics’, Archives of General Psychiatry, vol. 55, no. 4, p. 354, viewed 26 September 2020, .
    • MLA:
      Krystal, John H., et al. “Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics.” Archives of General Psychiatry, vol. 55, no. 4, Apr. 1998, p. 354. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=6020447.
    • Chicago/Turabian: Humanities:
      Krystal, John H., Ismene L. Petrakis, Elizabeth Webb, Ned L. Cooney, Laurence P. Karper, Sheila Namanworth, Philip Stetson, Louis A. Trevisan, and Dennis S. Charney. “Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics.” Archives of General Psychiatry 55, no. 4 (April 1998): 354. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=6020447.
    • Vancouver/ICMJE:
      Krystal JH, Petrakis IL, Webb E, Cooney NL, Karper LP, Namanworth S, et al. Dose-Related Ethanol-like Effects of the NMDA Antagonist, Ketamine, in Recently Detoxified Alcoholics. Archives of General Psychiatry [Internet]. 1998 Apr [cited 2020 Sep 26];55(4):354. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=6020447