Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: high and low serum thiocyanate groups as an indication of smoking

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Affiliation:
      University of Chicago, Multicenter Cooperative Study of the Pathobiological Determinants of Atherosclerosis, 5841 South Maryland Avenue, MC 3083, Chicago, Illinois 60637, USA
    • Note:
      This study was partially supported by HL 33740 and HL45715 and by a University of Chicago — Howard Hughes Foundation Grant.
    • Keywords:
      PDAY
      Atherosclerosis
      Lipid and apo E extent
      MØ numbers
      Risk factors
    • Abstract:
      Smoking is considered a major risk factor for the development and progression of atherosclerosis. The effects of apolipoprotein E (apo E) and macrophages in the pathogenesis and progression of human atherosclerosis have not been adequately elucidated even though they are frequent components of the diseased arterial intima. Anatomically standardized samples of arteries from young people whose risk factor indices indicated them as “smokers” or “non-smokers” have been studied micromorphometrically. It was found that smokers have a greater area in which apo E is deposited in the early stages of the disease than do non-smokers. Smokers also demonstrated greater “macrophage foam cell populations” than did non-smokers. The study also demonstrates a positive correlation between the number of macrophage foam cells and the extent of apo E deposition in the developing lesions of the thoracic and abdominal aortas of white men aged 30–34 years who have evidence of recent cigarette smoking as determined by their postmortem blood thiocyanate levels.
    • ISSN:
      0021-9150
    • Accession Number:
      10.1016/0021-9150(96)05825-X
    • Accession Number:
      002191509605825X
    • Copyright:
      Copyright @ unknown. Published by Elsevier Ireland Ltd
  • Citations
    • ABNT:
      BOTTI, T. P. et al. A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: high and low serum thiocyanate groups as an indication of smoking. Atherosclerosis, [s. l.], v. 124, n. 2, p. 191–202, 1996. DOI 10.1016/0021-9150(96)05825-X. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=002191509605825X. Acesso em: 22 out. 2020.
    • AMA:
      Botti TP, Amin H, Hiltscher L, Wissler RW. A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: high and low serum thiocyanate groups as an indication of smoking. Atherosclerosis. 1996;124(2):191-202. doi:10.1016/0021-9150(96)05825-X
    • APA:
      Botti, T. P., Amin, H., Hiltscher, L., & Wissler, R. W. (1996). A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: high and low serum thiocyanate groups as an indication of smoking. Atherosclerosis, 124(2), 191–202. https://doi.org/10.1016/0021-9150(96)05825-X
    • Chicago/Turabian: Author-Date:
      Botti, Torey P, Hetal Amin, Laura Hiltscher, and Robert W Wissler. 1996. “A Comparison of the Quantitation of Macrophage Foam Cell Populations and the Extent of Apolipoprotein E Deposition in Developing Atherosclerotic Lesions in Young People: High and Low Serum Thiocyanate Groups as an Indication of Smoking.” Atherosclerosis 124 (2): 191–202. doi:10.1016/0021-9150(96)05825-X.
    • Harvard:
      Botti, T. P. et al. (1996) ‘A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: high and low serum thiocyanate groups as an indication of smoking’, Atherosclerosis, 124(2), pp. 191–202. doi: 10.1016/0021-9150(96)05825-X.
    • Harvard: Australian:
      Botti, TP, Amin, H, Hiltscher, L & Wissler, RW 1996, ‘A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: high and low serum thiocyanate groups as an indication of smoking’, Atherosclerosis, vol. 124, no. 2, pp. 191–202, viewed 22 October 2020, .
    • MLA:
      Botti, Torey P., et al. “A Comparison of the Quantitation of Macrophage Foam Cell Populations and the Extent of Apolipoprotein E Deposition in Developing Atherosclerotic Lesions in Young People: High and Low Serum Thiocyanate Groups as an Indication of Smoking.” Atherosclerosis, vol. 124, no. 2, Jan. 1996, pp. 191–202. EBSCOhost, doi:10.1016/0021-9150(96)05825-X.
    • Chicago/Turabian: Humanities:
      Botti, Torey P, Hetal Amin, Laura Hiltscher, and Robert W Wissler. “A Comparison of the Quantitation of Macrophage Foam Cell Populations and the Extent of Apolipoprotein E Deposition in Developing Atherosclerotic Lesions in Young People: High and Low Serum Thiocyanate Groups as an Indication of Smoking.” Atherosclerosis 124, no. 2 (January 1, 1996): 191–202. doi:10.1016/0021-9150(96)05825-X.
    • Vancouver/ICMJE:
      Botti TP, Amin H, Hiltscher L, Wissler RW. A comparison of the quantitation of macrophage foam cell populations and the extent of apolipoprotein E deposition in developing atherosclerotic lesions in young people: high and low serum thiocyanate groups as an indication of smoking. Atherosclerosis [Internet]. 1996 Jan 1 [cited 2020 Oct 22];124(2):191–202. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=002191509605825X