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Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies

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  • Additional Information
    • Affiliation:
      University of Utah, Salt Lake City, UT, United States
    • Keywords:
      Cell sorting
      Cytogenetics
      High-resolution melting analysis
      Isothermal amplification
      Lab-on-a-chip
      Microfluidics
      Next-generation sequencing
      Polymerase chain reaction
    • Abstract:
      Advances in molecular biology are enabling rapid and efficient analyses for effective intervention in domains such as biology research, infectious disease management, food safety, and biodefense. The emergence of microfluidics and nanotechnologies has enabled both new capabilities and instrument sizes practical for point-of-care. It has also introduced new functionality, enhanced sensitivity, and reduced the time and cost involved in conventional molecular diagnostic techniques. This chapter reviews the application of microfluidics for molecular diagnostics methods such as nucleic acid amplification, next-generation sequencing, high-resolution melting analysis, cytogenetics, protein detection and analysis, and cell sorting. We also review microfluidic sample preparation platforms applied to molecular diagnostics and targeted to sample-in, answer-out capabilities.
    • ISBN:
      978-0-12-802971-8
    • ISBN:
      978-0-12-802988-6
    • ISBN:
      0-12-802971-4
    • ISBN:
      0-12-802988-9
    • Accession Number:
      10.1016/B978-0-12-802971-8.00011-0
    • Accession Number:
      B9780128029718000110
    • Copyright:
      Copyright © 2017 Elsevier Ltd All rights reserved.
  • Citations
    • ABNT:
      JAYAMOHAN, H. et al. Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies. Molecular Diagnostics, [s. l.], p. 197–217, 2017. DOI 10.1016/B978-0-12-802971-8.00011-0. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=B9780128029718000110. Acesso em: 29 set. 2020.
    • AMA:
      Jayamohan H, Romanov V, Li H, et al. Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies. Molecular Diagnostics. January 2017:197-217. doi:10.1016/B978-0-12-802971-8.00011-0
    • APA:
      Jayamohan, H., Romanov, V., Li, H., Son, J., Samuel, R., Nelson, J., & Gale, B. K. (2017). Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies. Molecular Diagnostics, 197–217. https://doi.org/10.1016/B978-0-12-802971-8.00011-0
    • Chicago/Turabian: Author-Date:
      Jayamohan, H., V. Romanov, H. Li, J. Son, R. Samuel, J. Nelson, and B.K. Gale. 2017. “Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies.” Molecular Diagnostics, January, 197–217. doi:10.1016/B978-0-12-802971-8.00011-0.
    • Harvard:
      Jayamohan, H. et al. (2017) ‘Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies’, Molecular Diagnostics, pp. 197–217. doi: 10.1016/B978-0-12-802971-8.00011-0.
    • Harvard: Australian:
      Jayamohan, H, Romanov, V, Li, H, Son, J, Samuel, R, Nelson, J & Gale, BK 2017, ‘Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies’, Molecular Diagnostics, pp. 197–217, viewed 29 September 2020, .
    • MLA:
      Jayamohan, H., et al. “Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies.” Molecular Diagnostics, Jan. 2017, pp. 197–217. EBSCOhost, doi:10.1016/B978-0-12-802971-8.00011-0.
    • Chicago/Turabian: Humanities:
      Jayamohan, H., V. Romanov, H. Li, J. Son, R. Samuel, J. Nelson, and B.K. Gale. “Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies.” Molecular Diagnostics, January 1, 2017, 197–217. doi:10.1016/B978-0-12-802971-8.00011-0.
    • Vancouver/ICMJE:
      Jayamohan H, Romanov V, Li H, Son J, Samuel R, Nelson J, et al. Chapter 11 - Advances in Microfluidics and Lab-on-a-Chip Technologies. Molecular Diagnostics [Internet]. 2017 Jan 1 [cited 2020 Sep 29];197–217. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=B9780128029718000110