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The role of vitamin D in the prevention of late-life depression

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  • Author(s): Okereke, Olivia I. a, b, c, ⁎; Singh, Ankura a
  • Source:
    In Journal of Affective Disorders 1 July 2016 198:1-14
  • Publication Information:
    Elsevier B.V.
  • Document Type:
    Review Article
  • Additional Information
    • Affiliation:
      a Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States
      b Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States
      c Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115 United States
    • Keywords:
      25-Hydroxyvitamin D
      Cholecalciferol
      Mood
      Geriatric
      Epidemiology
    • Abstract:
      Background In this article, we review current evidence regarding potential benefits of vitamin D for improving mood and reducing depression risk in older adults. We summarize gaps in knowledge and describe future efforts that may clarify the role of vitamin D in late-life depression prevention.
    • Abstract:
      Results Twenty observational (cross-sectional and prospective) studies and 10 randomized trials (nine were randomized placebo-controlled trials [RCTs]; one was a randomized blinded comparison trial) were reviewed. Inverse associations of vitamin D blood level or vitamin D intake with depression were found in 13 observational studies; three identified prospective relations. Results from all but one of the RCTs showed no statistically significant differences in depression outcomes between vitamin D and placebo groups.
    • Abstract:
      Limitations Observational studies were mostly cross-sectional and frequently lacked adequate control of confounding. RCTs often featured low treatment doses, suboptimal post-intervention changes in biochemical levels of vitamin D, and/or short trial durations.
    • Abstract:
      Conclusion Vitamin D level-mood associations were observed in most, but not all, observational studies; results indicated that vitamin D deficiency may be a risk factor for late-life depression. However, additional data from well-designed RCTs are required to determine the impact of vitamin D in late-life depression prevention.
    • Abstract:
      @@@@Highlights •Preventing late-life depression is a priority, and diet may be a useful strategy.•Low vitamin D is related to adverse brain and behavior outcomes in animal models.•Observational data suggested vitamin D-mood links but were mostly cross-sectional.•Vitamin D supplementation was related to better later-life mood in only one RCT.•RCT limitations: low doses, suboptimal change in vitamin D levels, short durations.
    • ISSN:
      0165-0327
    • Accession Number:
      10.1016/j.jad.2016.03.022
    • Accession Number:
      S0165032715310260
    • Copyright:
      Copyright © 2016 Elsevier B.V. All rights reserved.
  • Citations
    • ABNT:
      OKEREKE, O. I.; SINGH, A. The role of vitamin D in the prevention of late-life depression. Journal of Affective Disorders, [s. l.], v. 198, p. 1–14, 2016. DOI 10.1016/j.jad.2016.03.022. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0165032715310260. Acesso em: 24 nov. 2020.
    • AMA:
      Okereke OI, Singh A. The role of vitamin D in the prevention of late-life depression. Journal of Affective Disorders. 2016;198:1-14. doi:10.1016/j.jad.2016.03.022
    • APA:
      Okereke, O. I., & Singh, A. (2016). The role of vitamin D in the prevention of late-life depression. Journal of Affective Disorders, 198, 1–14. https://doi.org/10.1016/j.jad.2016.03.022
    • Chicago/Turabian: Author-Date:
      Okereke, Olivia I., and Ankura Singh. 2016. “The Role of Vitamin D in the Prevention of Late-Life Depression.” Journal of Affective Disorders 198 (July): 1–14. doi:10.1016/j.jad.2016.03.022.
    • Harvard:
      Okereke, O. I. and Singh, A. (2016) ‘The role of vitamin D in the prevention of late-life depression’, Journal of Affective Disorders, 198, pp. 1–14. doi: 10.1016/j.jad.2016.03.022.
    • Harvard: Australian:
      Okereke, OI & Singh, A 2016, ‘The role of vitamin D in the prevention of late-life depression’, Journal of Affective Disorders, vol. 198, pp. 1–14, viewed 24 November 2020, .
    • MLA:
      Okereke, Olivia I., and Ankura Singh. “The Role of Vitamin D in the Prevention of Late-Life Depression.” Journal of Affective Disorders, vol. 198, July 2016, pp. 1–14. EBSCOhost, doi:10.1016/j.jad.2016.03.022.
    • Chicago/Turabian: Humanities:
      Okereke, Olivia I., and Ankura Singh. “The Role of Vitamin D in the Prevention of Late-Life Depression.” Journal of Affective Disorders 198 (July 1, 2016): 1–14. doi:10.1016/j.jad.2016.03.022.
    • Vancouver/ICMJE:
      Okereke OI, Singh A. The role of vitamin D in the prevention of late-life depression. Journal of Affective Disorders [Internet]. 2016 Jul 1 [cited 2020 Nov 24];198:1–14. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0165032715310260