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Impact of smoking cessation on ambulatory blood pressure and heart rate in postmenopausal women

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  • Additional Information
    • Affiliation:
      a Section of Hypertension and Clinical Pharmacology (CAO, WBW, SG), Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA
      b Department of Psychiatry (JLC, JRVK), University of Connecticut Health Center, Farmington, Connecticut, USA
      c Department of Preventive Medicine and Internal Medicine (JSA), University of Kansas School of Medicine, Kansas City, Kansas, USA
    • Note:
      This work was supported by the University of Connecticut Research Initiation Support and Enhancement Program; NIH General Clinical Research Center Grant M01RR06192; The Claude Pepper Older Americans Independence Center AG13631; NIH Grant CA84733; and The Catherine and Patrick Weldon Donaghue Medical Research Foundation (Hartford, CT).
    • Keywords:
      Ambulatory blood pressure
      smoking cessation
      heart rate
      rate–pressure product
      catecholamines
      sympathetic nervous system
    • Abstract:
      Background: Smoking and hypertension interact to increase the incidence of cardiovascular disease; however, little is known about the effects of smoking cessation on blood pressure (BP) control. We prospectively evaluated the impact of smoking cessation on clinic and ambulatory BP and heart rate (HR) in stage 1 hypertensive and normotensive postmenopausal women. Methods: A total of 66 women were randomly assigned using a 3:1 randomization scheme to immediate smoking cessation or to a wait list control group. Clinic and ambulatory BP and HR, and 24-h urinary catecholamine concentrations were obtained at baseline and again at 6 weeks. Carbon monoxide levels and self-report were used to assess compliance with smoking cessation. Results: Ambulatory monitoring showed that the awake SBP decreased by 3.6 ± 1.9 mm Hg in the treated subjects who quit smoking ( n = 19), whereas in the control group ( n = 15) there was an increase of 1.7 ± 2.4 mm Hg ( P = .045). Awake HR decreased after smoking cessation by 7 ± 1 beats/min and did not change (0 ± 1 beat/min) in the control group ( P = .001). Blood pressure and HR did not significantly change during sleep after smoking cessation. Changes in the awake HR correlated with changes in urinary epinephrine concentrations (r = 0.58, P = .001), and norepinephrine concentrations (r = 0.45, P = .001), There was no significant change in clinic systolic BP, diastolic BP, or HR between groups. Conclusions: Smoking cessation reduces systolic BP and HR during the daytime, when patients typically smoke. These hemodynamic changes are due in part to reductions in sympathetic nervous system activity.
    • ISSN:
      0895-7061
    • Accession Number:
      10.1016/S0895-7061(01)02147-1
    • Accession Number:
      S0895706101021471
    • Copyright:
      Copyright @ 2001 American Journal of Hypertension, Ltd. Published by Elsevier Inc. All rights reserved.
  • Citations
    • ABNT:
      ONCKEN, C. A. et al. Impact of smoking cessation on ambulatory blood pressure and heart rate in postmenopausal women. American Journal of Hypertension, [s. l.], v. 14, n. 9, p. 942–949, 2001. DOI 10.1016/S0895-7061(01)02147-1. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0895706101021471. Acesso em: 22 out. 2020.
    • AMA:
      Oncken CA, White WB, Cooney JL, Van Kirk JR, Ahluwalia JS, Giacco S. Impact of smoking cessation on ambulatory blood pressure and heart rate in postmenopausal women. American Journal of Hypertension. 2001;14(9):942-949. doi:10.1016/S0895-7061(01)02147-1
    • APA:
      Oncken, C. A., White, W. B., Cooney, J. L., Van Kirk, J. R., Ahluwalia, J. S., & Giacco, S. (2001). Impact of smoking cessation on ambulatory blood pressure and heart rate in postmenopausal women. American Journal of Hypertension, 14(9), 942–949. https://doi.org/10.1016/S0895-7061(01)02147-1
    • Chicago/Turabian: Author-Date:
      Oncken, Cheryl A, William B White, Judith L Cooney, Jeffrey R Van Kirk, Jasjit S Ahluwalia, and Sharon Giacco. 2001. “Impact of Smoking Cessation on Ambulatory Blood Pressure and Heart Rate in Postmenopausal Women.” American Journal of Hypertension 14 (9): 942–49. doi:10.1016/S0895-7061(01)02147-1.
    • Harvard:
      Oncken, C. A. et al. (2001) ‘Impact of smoking cessation on ambulatory blood pressure and heart rate in postmenopausal women’, American Journal of Hypertension, 14(9), pp. 942–949. doi: 10.1016/S0895-7061(01)02147-1.
    • Harvard: Australian:
      Oncken, CA, White, WB, Cooney, JL, Van Kirk, JR, Ahluwalia, JS & Giacco, S 2001, ‘Impact of smoking cessation on ambulatory blood pressure and heart rate in postmenopausal women’, American Journal of Hypertension, vol. 14, no. 9, pp. 942–949, viewed 22 October 2020, .
    • MLA:
      Oncken, Cheryl A., et al. “Impact of Smoking Cessation on Ambulatory Blood Pressure and Heart Rate in Postmenopausal Women.” American Journal of Hypertension, vol. 14, no. 9, Jan. 2001, pp. 942–949. EBSCOhost, doi:10.1016/S0895-7061(01)02147-1.
    • Chicago/Turabian: Humanities:
      Oncken, Cheryl A, William B White, Judith L Cooney, Jeffrey R Van Kirk, Jasjit S Ahluwalia, and Sharon Giacco. “Impact of Smoking Cessation on Ambulatory Blood Pressure and Heart Rate in Postmenopausal Women.” American Journal of Hypertension 14, no. 9 (January 1, 2001): 942–49. doi:10.1016/S0895-7061(01)02147-1.
    • Vancouver/ICMJE:
      Oncken CA, White WB, Cooney JL, Van Kirk JR, Ahluwalia JS, Giacco S. Impact of smoking cessation on ambulatory blood pressure and heart rate in postmenopausal women. American Journal of Hypertension [Internet]. 2001 Jan 1 [cited 2020 Oct 22];14(9):942–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0895706101021471