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Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study

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  • Additional Information
    • Author(s):
    • Abstract:
      Objective: Peripheral inflammation has been associated with adverse effects on cognition and brain structure in late life, a process called 'inflammaging.' Identifying biomarkers of preclinical cognitive decline is critical in the development of preventative therapies, and peripheral inflammation may be able to serve as an indicator of cognitive decline. However, little is known regarding the relationship between peripheral inflammation and brain structure and function among older adults.Methods: Twenty-four older adults (mean age = 78) underwent a functional magnetic resonance imaging (fMRI) resting state functional connectivity scan, and a subset (n = 14) completed the n-Back working memory task in the scanner. All participants completed a blood draw, and inflammation was measured with interleukin 6 (IL-6) and C-Reactive Protein (CRP).Results: Surprisingly, age was unrelated to measures of inflammation (IL-6, CRP) or brain function (default mode network (DMN) connectivity; working memory performance; blood oxygenation level dependent (BOLD) activation with higher working memory load). However, lower functional connectivity between the left parietal seed and all other DMN regions was associated with higher levels of IL-6 and CRP. Additionally, greater plasma concentration of IL-6 was associated with lower BOLD activation in the left middle frontal gyrus in response to increased working memory load.Conclusions: These preliminary findings support the importance of IL-6 and CRP in brain function among older adults. Frontal and parietal regions may be particularly sensitive to the effects of inflammation. Additionally, these findings provide preliminary evidence of inflammatory contributions to level of neural activity, even after accounting for vascular risk factors. ABSTRACT FROM AUTHOR (Copyright of International Journal of Geriatric Psychiatry is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.)
    • Accession Number:
      COGNITION disorder patients; FUNCTIONAL magnetic resonance imaging; MAGNETIC resonance imaging complications; aging; cognitive health; functional MRI; inflammation; resting state connectivity
    • Publication Information:
      Publication Type: Journal Article ISSN: 0885-6230
    • Accession Number:
      EP121164957
  • Citations
    • ABNT:
      DEV, S. I. et al. Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study. International Journal of Geriatric Psychiatry, [s. l.], v. 32, n. 3, p. 341–349, 2017. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121164957. Acesso em: 22 out. 2020.
    • AMA:
      Dev SI, Moore RC, Soontornniyomkij B, Achim CL, Jeste DV, Eyler LT. Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study. International Journal of Geriatric Psychiatry. 2017;32(3):341-349. Accessed October 22, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121164957
    • APA:
      Dev, S. I., Moore, R. C., Soontornniyomkij, B., Achim, C. L., Jeste, D. V., & Eyler, L. T. (2017). Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study. International Journal of Geriatric Psychiatry, 32(3), 341–349.
    • Chicago/Turabian: Author-Date:
      Dev, Sheena I., Raeanne C. Moore, Benchawanna Soontornniyomkij, Cristian L. Achim, Dilip V. Jeste, and Lisa T. Eyler. 2017. “Peripheral Inflammation Related to Lower FMRI Activation during a Working Memory Task and Resting Functional Connectivity among Older Adults: A Preliminary Study.” International Journal of Geriatric Psychiatry 32 (3): 341–49. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121164957.
    • Harvard:
      Dev, S. I. et al. (2017) ‘Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study’, International Journal of Geriatric Psychiatry, 32(3), pp. 341–349. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121164957 (Accessed: 22 October 2020).
    • Harvard: Australian:
      Dev, SI, Moore, RC, Soontornniyomkij, B, Achim, CL, Jeste, DV & Eyler, LT 2017, ‘Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study’, International Journal of Geriatric Psychiatry, vol. 32, no. 3, pp. 341–349, viewed 22 October 2020, .
    • MLA:
      Dev, Sheena I., et al. “Peripheral Inflammation Related to Lower FMRI Activation during a Working Memory Task and Resting Functional Connectivity among Older Adults: A Preliminary Study.” International Journal of Geriatric Psychiatry, vol. 32, no. 3, Mar. 2017, pp. 341–349. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121164957.
    • Chicago/Turabian: Humanities:
      Dev, Sheena I., Raeanne C. Moore, Benchawanna Soontornniyomkij, Cristian L. Achim, Dilip V. Jeste, and Lisa T. Eyler. “Peripheral Inflammation Related to Lower FMRI Activation during a Working Memory Task and Resting Functional Connectivity among Older Adults: A Preliminary Study.” International Journal of Geriatric Psychiatry 32, no. 3 (March 1, 2017): 341–49. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121164957.
    • Vancouver/ICMJE:
      Dev SI, Moore RC, Soontornniyomkij B, Achim CL, Jeste DV, Eyler LT. Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study. International Journal of Geriatric Psychiatry [Internet]. 2017 Mar 1 [cited 2020 Oct 22];32(3):341–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121164957