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Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study

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  • Additional Information
    • Author(s):
    • Abstract:
      Objectives: To examine the relationship between anxiety, depression, apathy, and cognitive decline in Parkinson disease (PD).Design: Longitudinal study design to assess whether specific neuropsychiatric, demographic, and clinical features predict future cognitive decline.Setting: Veterans Affairs San Diego Medical Center and the University of California, San Diego.Participants: PD patients (N = 68) and healthy controls (N = 30).Measurements: Participants were administered self-report measures of depression (Geriatric Depression Scale), anxiety (State Trait Anxiety Scale), and apathy (Apathy Scale), and a comprehensive neuropsychological battery assessing attention, language, visuospatial function, verbal and visual learning and memory, and executive function. Participants were tested at baseline and after an approximate 2-year period.Results: Anxiety and depression at baseline were the strongest predictors of longitudinal decline on measures of verbal and visual learning, over and above other clinical and demographic characteristics. However, baseline neuropsychiatric symptoms did not significantly correlate with decline in other cognitive domains. No significant correlations were detected between neuropsychiatric symptoms and cognition in the healthy control group.Conclusions: These results suggest that anxiety and depression in PD may be risk factors for subsequent declines in learning. Emerging evidence suggests nonmotor symptoms are critical determinants of PD prognosis, and the results of this study highlight the importance of assessment of depression and anxiety early in PD. ABSTRACT FROM AUTHOR (Copyright of American Journal of Geriatric Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.)
    • Accession Number:
      PSYCHOLOGY; ANXIETY diagnosis; PARKINSON'S disease diagnosis; cognitive decline; longitudinal study; Neuropsychiatric symptoms; Parkinson disease
    • Publication Information:
      Publication Type: Journal Article ISSN: 1064-7481
    • Accession Number:
      EP121475580
  • Citations
    • ABNT:
      PIROGOVSKY-TURK, E. et al. Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study. American Journal of Geriatric Psychiatry, [s. l.], v. 25, n. 3, p. 279–289, 2017. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121475580. Acesso em: 20 out. 2020.
    • AMA:
      Pirogovsky-Turk E, Moore RC, Filoteo JV, et al. Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study. American Journal of Geriatric Psychiatry. 2017;25(3):279-289. Accessed October 20, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121475580
    • APA:
      Pirogovsky-Turk, E., Moore, R. C., Filoteo, J. V., Litvan, I., Song, D. D., Lessig, S. L., & Schiehser, D. M. (2017). Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study. American Journal of Geriatric Psychiatry, 25(3), 279–289.
    • Chicago/Turabian: Author-Date:
      Pirogovsky-Turk, Eva, Raeanne C. Moore, J. Vincent Filoteo, Irene Litvan, David D. Song, Stephanie L. Lessig, and Dawn M. Schiehser. 2017. “Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study.” American Journal of Geriatric Psychiatry 25 (3): 279–89. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121475580.
    • Harvard:
      Pirogovsky-Turk, E. et al. (2017) ‘Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study’, American Journal of Geriatric Psychiatry, 25(3), pp. 279–289. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121475580 (Accessed: 20 October 2020).
    • Harvard: Australian:
      Pirogovsky-Turk, E, Moore, RC, Filoteo, JV, Litvan, I, Song, DD, Lessig, SL & Schiehser, DM 2017, ‘Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study’, American Journal of Geriatric Psychiatry, vol. 25, no. 3, pp. 279–289, viewed 20 October 2020, .
    • MLA:
      Pirogovsky-Turk, Eva, et al. “Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study.” American Journal of Geriatric Psychiatry, vol. 25, no. 3, Mar. 2017, pp. 279–289. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121475580.
    • Chicago/Turabian: Humanities:
      Pirogovsky-Turk, Eva, Raeanne C. Moore, J. Vincent Filoteo, Irene Litvan, David D. Song, Stephanie L. Lessig, and Dawn M. Schiehser. “Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study.” American Journal of Geriatric Psychiatry 25, no. 3 (March 1, 2017): 279–89. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121475580.
    • Vancouver/ICMJE:
      Pirogovsky-Turk E, Moore RC, Filoteo JV, Litvan I, Song DD, Lessig SL, et al. Neuropsychiatric Predictors of Cognitive Decline in Parkinson Disease: A Longitudinal Study. American Journal of Geriatric Psychiatry [Internet]. 2017 Mar 1 [cited 2020 Oct 20];25(3):279–89. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP121475580