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Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI

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  • Additional Information
    • Author(s):
    • Abstract:
      Abstract: Background: Decreased speed of information processing is a hallmark of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Recent studies suggest that response speed (RS) measures are very sensitive indicators of changes in longitudinal follow-up studies. Insight into the psycho-physiological underpinnings of slowed RS can be provided by measuring the associated event-related potentials (ERP). Aims: The current study aims to investigate the relation between RS and its psycho-physiological correlates in AD and MCI. Methods: Fifteen psychoactive drug-naïve AD patients, 20 MCI patients and twenty age-matched, healthy control subjects participated. Response speed was measured during a simple (SRT) and choice reaction time task (CRT). An oddball and contingent negative variation (CNV) paradigm were used to elicit ERP. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment one week after the first. Results: The SRT and CRT distinguished the patient groups significantly. The P300 amplitude and latency also distinguished the groups and showed a significant correlation with response speed. The CNV amplitude did not reveal a significant difference between groups and also showed a low TRR. The TRR of the SRT, CRT and P300 amplitude and latency in general was moderate to high. The current study suggests that response speed measures on a behavioural and psycho-physiological level deserve attention as a possible marker in the diagnosis and follow-up of AD. Copyright 2009 Elsevier
    • Publication Information:
      Publication Type: Journal Article ISSN: 0278-2626
    • Accession Number:
      EP36682582
  • Citations
    • ABNT:
      VAN DEURSEN, J. A. et al. Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI. Brain and Cognition, [s. l.], v. 69, n. 3, p. 592–599, 2009. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP36682582. Acesso em: 28 out. 2020.
    • AMA:
      van Deursen JA, Vuurman EFPM, Smits LL, Verhey FRJ, Riedel WJ. Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI. Brain and Cognition. 2009;69(3):592-599. Accessed October 28, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP36682582
    • APA:
      van Deursen, J. A., Vuurman, E. F. P. M., Smits, L. L., Verhey, F. R. J., & Riedel, W. J. (2009). Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI. Brain and Cognition, 69(3), 592–599.
    • Chicago/Turabian: Author-Date:
      van Deursen, J.A., E.F.P.M. Vuurman, L.L. Smits, F.R.J. Verhey, and W.J. Riedel. 2009. “Response Speed, Contingent Negative Variation and P300 in Alzheimer’s Disease and MCI.” Brain and Cognition 69 (3): 592–99. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP36682582.
    • Harvard:
      van Deursen, J. A. et al. (2009) ‘Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI’, Brain and Cognition, 69(3), pp. 592–599. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP36682582 (Accessed: 28 October 2020).
    • Harvard: Australian:
      van Deursen, JA, Vuurman, EFPM, Smits, LL, Verhey, FRJ & Riedel, WJ 2009, ‘Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI’, Brain and Cognition, vol. 69, no. 3, pp. 592–599, viewed 28 October 2020, .
    • MLA:
      van Deursen, J. A., et al. “Response Speed, Contingent Negative Variation and P300 in Alzheimer’s Disease and MCI.” Brain and Cognition, vol. 69, no. 3, Mar. 2009, pp. 592–599. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP36682582.
    • Chicago/Turabian: Humanities:
      van Deursen, J.A., E.F.P.M. Vuurman, L.L. Smits, F.R.J. Verhey, and W.J. Riedel. “Response Speed, Contingent Negative Variation and P300 in Alzheimer’s Disease and MCI.” Brain and Cognition 69, no. 3 (March 1, 2009): 592–99. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP36682582.
    • Vancouver/ICMJE:
      van Deursen JA, Vuurman EFPM, Smits LL, Verhey FRJ, Riedel WJ. Response speed, contingent negative variation and P300 in Alzheimer’s disease and MCI. Brain and Cognition [Internet]. 2009 Mar 1 [cited 2020 Oct 28];69(3):592–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=gnh&AN=EP36682582