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HLA-B*1301 as a biomarker for genetic susceptibility of hypersensitivity dermatitis induced by trichloroethylene among workers in China.

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  • Additional Information
    • Abstract:
      BACKGROUND: Trichloroethylene (TCE) is used extensively as an industrial solvent and has been recognized as one of the major environmental pollutants. To date, > 200 cases of TCE-induced hypersensitivity dermatitis among exposed workers have been reported worldwide, and TCE exposure has become one of the critical occupational health issues in Asia. OBJECTIVES: The study aimed to identify genetic susceptible biomarkers associated with the TCE-induced hypersensitivity dermatitis in genes located in the human leukocyte antigen (HLA) region. METHODS: From 1998 to 2006, 121 cases with TCE-induced hypersensitivity dermatitis and 142 tolerant controls were recruited into the population-based case-control study. We determined HLA alleles B, DRB1, DQA1, and DQB1, by sequence-based typing. p-Values were corrected for comparisons of multiple HLA alleles. In addition, we compared and analyzed the structure character of amino acid residues of HLA molecules found in participants. RESULTS: We obtained complete genotyping data of 113 cases and 142 controls. The allele HLA-B*1301 was present in 83 (73.5%) of 113 patients compared with 13 (9.2%) of 142 tolerant workers (odds ratio = 27.5; 95% confidence interval, 13.5-55.7; corrected p = 1.48 x 10(-21)). In addition, the HLA-B*44 alleles were present in 6.2% (7/113) of patients, but were absent in TCE-tolerant workers. Residue 95 shared by HLA-B*1301 and HLA-B*44 molecules formed a different pocket F than other residues. CONCLUSIONS: The allele HLA-B*1301 is strongly associated with TCE-induced hypersensitivity dermatitis among exposed workers and might be used as a biomarker to predict high risk individuals to TCE. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      0091-6765
    • Accession Number:
      105846206
  • Citations
    • ABNT:
      LI H et al. HLA-B*1301 as a biomarker for genetic susceptibility of hypersensitivity dermatitis induced by trichloroethylene among workers in China. Environmental Health Perspectives, [s. l.], v. 115, n. 11, p. 1553–1556, 2007. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=105846206. Acesso em: 21 out. 2020.
    • AMA:
      Li H, Dai Y, Huang H, et al. HLA-B*1301 as a biomarker for genetic susceptibility of hypersensitivity dermatitis induced by trichloroethylene among workers in China. Environmental Health Perspectives. 2007;115(11):1553-1556. Accessed October 21, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=105846206
    • APA:
      Li H, Dai Y, Huang H, Li L, Leng S, Cheng J, Niu Y, Duan H, Liu Q, Zhang X, Huang X, Xie J, Feng Z, Wang J, He J, & Zheng Y. (2007). HLA-B*1301 as a biomarker for genetic susceptibility of hypersensitivity dermatitis induced by trichloroethylene among workers in China. Environmental Health Perspectives, 115(11), 1553–1556.
    • Chicago/Turabian: Author-Date:
      Li H, Dai Y, Huang H, Li L, Leng S, Cheng J, Niu Y, et al. 2007. “HLA-B*1301 as a Biomarker for Genetic Susceptibility of Hypersensitivity Dermatitis Induced by Trichloroethylene among Workers in China.” Environmental Health Perspectives 115 (11): 1553–56. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=105846206.
    • Harvard:
      Li H et al. (2007) ‘HLA-B*1301 as a biomarker for genetic susceptibility of hypersensitivity dermatitis induced by trichloroethylene among workers in China’, Environmental Health Perspectives, 115(11), pp. 1553–1556. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=105846206 (Accessed: 21 October 2020).
    • Harvard: Australian:
      Li H, Dai Y, Huang H, Li L, Leng S, Cheng J, Niu Y, Duan H, Liu Q, Zhang X, Huang X, Xie J, Feng Z, Wang J, He J & Zheng Y 2007, ‘HLA-B*1301 as a biomarker for genetic susceptibility of hypersensitivity dermatitis induced by trichloroethylene among workers in China’, Environmental Health Perspectives, vol. 115, no. 11, pp. 1553–1556, viewed 21 October 2020, .
    • MLA:
      Li H, et al. “HLA-B*1301 as a Biomarker for Genetic Susceptibility of Hypersensitivity Dermatitis Induced by Trichloroethylene among Workers in China.” Environmental Health Perspectives, vol. 115, no. 11, Nov. 2007, pp. 1553–1556. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=105846206.
    • Chicago/Turabian: Humanities:
      Li H, Dai Y, Huang H, Li L, Leng S, Cheng J, Niu Y, et al. “HLA-B*1301 as a Biomarker for Genetic Susceptibility of Hypersensitivity Dermatitis Induced by Trichloroethylene among Workers in China.” Environmental Health Perspectives 115, no. 11 (November 2007): 1553–56. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=105846206.
    • Vancouver/ICMJE:
      Li H, Dai Y, Huang H, Li L, Leng S, Cheng J, et al. HLA-B*1301 as a biomarker for genetic susceptibility of hypersensitivity dermatitis induced by trichloroethylene among workers in China. Environmental Health Perspectives [Internet]. 2007 Nov [cited 2020 Oct 21];115(11):1553–6. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=105846206