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Decreased cerebral blood flow velocity in apolipoprotein E ℇ4 allele carriers with mild cognitive impairment.

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    • Abstract:
      The aim of this study was to investigate the changes in cerebral blood flow velocity (CBFV) and its relation to apolipoprotein E (apoE) ℇ4 allele in mild cognitive impairment (MCI). Thirty MCI and 30 controls were assessed using Mini-Mental State Examination (MMSE) and Cambridge Cognitive Examination-Chinese version (CAMCOG-C), and then insonated in the anterior (ACA), middle (MCA) and basilar (BA) cerebral arteries using transcranial Doppler ultrasonography. Compared with controls, MCI showed significant decreases in the mean ( Vm), systolic ( Vs) and diastolic ( Vd) CBFV, bilaterally in MCA and ACA ( P < 0.05–0.001), but not in BA. Compared with 17 apoE ℇ4 allele non-carriers, 13 carriers in MCI showed significant CBFV decreases, bilaterally in MCA ( P < 0.05–0.001). Our findings, the decreased CBFV in apoE ℇ4 allele carriers with MCI, suggest that a large sample and longitudinal study in CBFV and cognitive changes may have the implications on early diagnosis of Alzheimer's disease. [ABSTRACT FROM AUTHOR]
    • Abstract:
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