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Expression of Phosphatase of Regenerating Liver 1 and 3 mRNA in Esophageal Squamous Cell Carcinoma.

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  • Additional Information
    • Subject Terms:
    • Abstract:
      Context.-Phosphatase of regenerating liver (PRL) 3 messenger RNA (mRNA) was reported to express in human colorectal, gastric, ovarian, breast, and hepatic cancers. Objective.-To examine the expression of PRL-1 and PRL-3 mRNAs in human esophageal squamous cell carcinoma (ESCC). Design.-Expression of PRL-1 and PRL-3 mRNA was examined with reverse transcriptase-polymerase chain reaction in fresh tissue collected from 40 cases of ESCC with matched lymph node metastasis in 21 cases. The association of expression of PRL-1 and PRL-3 mRNAs with clinicopathologic parameters was analyzed. Results.-The frequencies of PRL-1 and PRL-3 mRNA expression were significantly higher in ESCC than in normal esophageal tissue (P = .001; P = .01) and also significantly higher in ESCC with lymph node metastasis than in those without lymph node metastasis (P = .01; P = .03). The levels of PRL-1 and PRL-3 mRNA expression were significantly higher in ESCC with lymph node metastasis than in those without lymph node metastasis (P = .04; P = .04). The frequencies and levels of PRL-1 and PRL-3 mRNA expression were correlated with the later stages but not with tumor differentiation, tumor location in the esophagus, patient's sex, and age. Conclusions.-PRL-1 and PRL-3 mRNAs may be involved in and used to predict the metastasis of ESCC. The possibility of using PRL-1 and PRL-3 as the therapeutical target is also discussed. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Archives of Pathology & Laboratory Medicine is the property of College of American Pathologists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      0003-9985
    • Accession Number:
      33944703
  • Citations
    • ABNT:
      YU-QIONG LIU et al. Expression of Phosphatase of Regenerating Liver 1 and 3 mRNA in Esophageal Squamous Cell Carcinoma. Archives of Pathology & Laboratory Medicine, [s. l.], v. 132, n. 8, p. 1307–1312, 2008. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=33944703. Acesso em: 23 out. 2020.
    • AMA:
      Yu-Qiong Liu, Hui-Siang Li, Xi Lou, Jun-Yi Lei. Expression of Phosphatase of Regenerating Liver 1 and 3 mRNA in Esophageal Squamous Cell Carcinoma. Archives of Pathology & Laboratory Medicine. 2008;132(8):1307-1312. Accessed October 23, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=33944703
    • APA:
      Yu-Qiong Liu, Hui-Siang Li, Xi Lou, & Jun-Yi Lei. (2008). Expression of Phosphatase of Regenerating Liver 1 and 3 mRNA in Esophageal Squamous Cell Carcinoma. Archives of Pathology & Laboratory Medicine, 132(8), 1307–1312.
    • Chicago/Turabian: Author-Date:
      Yu-Qiong Liu, Hui-Siang Li, Xi Lou, and Jun-Yi Lei. 2008. “Expression of Phosphatase of Regenerating Liver 1 and 3 MRNA in Esophageal Squamous Cell Carcinoma.” Archives of Pathology & Laboratory Medicine 132 (8): 1307–12. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=33944703.
    • Harvard:
      Yu-Qiong Liu et al. (2008) ‘Expression of Phosphatase of Regenerating Liver 1 and 3 mRNA in Esophageal Squamous Cell Carcinoma’, Archives of Pathology & Laboratory Medicine, 132(8), pp. 1307–1312. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=33944703 (Accessed: 23 October 2020).
    • Harvard: Australian:
      Yu-Qiong Liu, Hui-Siang Li, Xi Lou & Jun-Yi Lei 2008, ‘Expression of Phosphatase of Regenerating Liver 1 and 3 mRNA in Esophageal Squamous Cell Carcinoma’, Archives of Pathology & Laboratory Medicine, vol. 132, no. 8, pp. 1307–1312, viewed 23 October 2020, .
    • MLA:
      Yu-Qiong Liu, et al. “Expression of Phosphatase of Regenerating Liver 1 and 3 MRNA in Esophageal Squamous Cell Carcinoma.” Archives of Pathology & Laboratory Medicine, vol. 132, no. 8, Aug. 2008, pp. 1307–1312. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=33944703.
    • Chicago/Turabian: Humanities:
      Yu-Qiong Liu, Hui-Siang Li, Xi Lou, and Jun-Yi Lei. “Expression of Phosphatase of Regenerating Liver 1 and 3 MRNA in Esophageal Squamous Cell Carcinoma.” Archives of Pathology & Laboratory Medicine 132, no. 8 (August 2008): 1307–12. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=33944703.
    • Vancouver/ICMJE:
      Yu-Qiong Liu, Hui-Siang Li, Xi Lou, Jun-Yi Lei. Expression of Phosphatase of Regenerating Liver 1 and 3 mRNA in Esophageal Squamous Cell Carcinoma. Archives of Pathology & Laboratory Medicine [Internet]. 2008 Aug [cited 2020 Oct 23];132(8):1307–12. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hch&AN=33944703