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Pharmacokinetics and bioavailability of cefquinome in healthy piglets.

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    • Abstract:
      A study on bioavailability and pharmacokinetics of cefquinome in piglets was conducted after intravenous (i.v.) and intramuscular (i.m.) administrations of 2.0 mg/kg of body weight, respectively. Plasma concentrations were measured by high-performance liquid chromatography assay with UV detector at 268-nm wavelength. Plasma concentration–time data after i.v. administration were best fit by a two-compartment model. The pharmacokinetic values were distribution half-life 0.27 ± 0.21 h, elimination half-life 1.85 ± 1.11 h, total body clearance 0.26 ± 0.08 L/kg·h, area under curve 8.07 ± 1.91 μg·h/mL and volume of distribution at steady state 0.46 ± 0.10 L/kg. Plasma concentration–time data after i.m. administration were also best fit by a two-compartment model. The pharmacokinetic parameters were distribution half-life 0.88 ± 0.42 h, elimination half-life 4.36 ± 2.35 h, peak concentration 4.01 ± 0.57 μg/mL and bioavailability 95.13 ± 9.93%. [ABSTRACT FROM AUTHOR]
    • Abstract:
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