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Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir.

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  • Additional Information
    • Author(s):
    • Address:
      Air and Fire, Science for Life Laboratory, Tomtebodavägen 23 A, Solna, Sweden.
    • Publication Information:
      Sweden
    • Abstract:
      The objective of the article was to address this challenge from different aspects with several novel technologies, using both molecular and microfluidics-based tools. The results indicated the LIPS method might not be sufficient for latent HIV-1 reservoir detection, although it has been proposed to quantify the latent HIV-1 reservoir indirectly. Furthermore, the optimized RNAscope technique performed better than RNAflow for transcription and translation competent latent HIV-1 reservoir identification. Together, though further improvement and clinical verification are necessary, this article has contributed to the advancement of latent HIV-1 reservoir characterization and may facilitate future development of the latent HIV-1 reservoir targeting and clearance methods with the ultimate goal - to cure HIV-1 infection.
    • Subject Terms:
      Public Health
    • Subject Terms:
    • Accession Number:
      viral infections
    • CABICODES:
      Prion, Viral, Bacterial and Fungal Pathogens of Humans (VV210) (New March 2000)
      Techniques and Methodology (ZZ900)
    • Publication Information:
      Thesis; URL:https://openarchive.ki.se/xmlui/handle/10616/46635
    • Accession Number:
      20203185629
    • Copyright:
      ©2019 CAB International
  • Citations
    • ABNT:
      ZHANG WANG. Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir. 2019. Karolinska Institutet, Stockholm; Sweden, 2019. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185629. Acesso em: 30 nov. 2020.
    • AMA:
      Zhang Wang. Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir. Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir. 2019:75. Accessed November 30, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185629
    • APA:
      Zhang Wang. (2019). Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir [Karolinska Institutet]. In Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir (p. 75).
    • Chicago/Turabian: Author-Date:
      Zhang Wang. 2019. “Development of Novel Molecular and Microfluidics Tools for Identification and Characterization of Latent HIV-1 Reservoir.” Development of Novel Molecular and Microfluidics Tools for Identification and Characterization of Latent HIV-1 Reservoir. Stockholm; Sweden: Karolinska Institutet. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185629.
    • Harvard:
      Zhang Wang (2019) Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir, Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir. Karolinska Institutet. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185629 (Accessed: 30 November 2020).
    • Harvard: Australian:
      Zhang Wang 2019, ‘Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir’, Karolinska Institutet, Stockholm; Sweden, Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir, p. 75, viewed 30 November 2020, .
    • MLA:
      Zhang Wang. “Development of Novel Molecular and Microfluidics Tools for Identification and Characterization of Latent HIV-1 Reservoir.” Development of Novel Molecular and Microfluidics Tools for Identification and Characterization of Latent HIV-1 Reservoir, Karolinska Institutet, 2019, p. 75. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185629.
    • Chicago/Turabian: Humanities:
      Zhang Wang. “Development of Novel Molecular and Microfluidics Tools for Identification and Characterization of Latent HIV-1 Reservoir.” Development of Novel Molecular and Microfluidics Tools for Identification and Characterization of Latent HIV-1 Reservoir. Karolinska Institutet, 2019. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185629.
    • Vancouver/ICMJE:
      Zhang Wang. Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir [Internet]. Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir. [Stockholm; Sweden]: Karolinska Institutet; 2019 [cited 2020 Nov 30]. p. 75. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185629