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Diet and the risk of latent autoimmune diabetes in adults (LADA) : studies on the association with fish and sweetened beverages.

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  • Additional Information
    • Author(s):
    • Address:
      Institutet för miljömedicin / Institute of Environmental Medicine, Karolinska Institutet, Sweden.
    • Publication Information:
      Sweden
    • Abstract:
      The aim of this thesis was to study the risk of LADA in relation to intakes of fish and sweetened beverages, two commonly consumed foods hypothesized to play a role in the development of both type 1 and type 2 diabetes. Analyses were based mainly on ESTRID, a Swedish case-control study with incident cases of LADA and type 2 diabetes, and population-based controls. All participants in ESTRID were aged ≥ 35 years and LADA was defined by the presence of glutamic acid decarboxylase autoantibodies (GADA) and a level of C-peptide indicating remaining insulin secretion. Data on intakes of fish and sweetened beverages were available from questionnaires and investigated in relation to risk of LADA and type 2 diabetes. One study was based on data from EPIC-InterAct, a case-cohort study with prospective data from eight European countries. In EPIC-InterAct, the interaction of baseline GADA positivity and self-reported dietary fish or plasma n-3 PUFA in relation to the risk of adult onset diabetes was assessed. Based on ESTRID, weekly fatty fish intake was associated with 49% reduced risk of LADA (odds ratio [OR] 1.51, 95% confidence interval [CI] 0.30-0.87), whereas no association was found for type 2 diabetes (OR 1.01, 95% CI 0.74-1.39). These findings were supported by the results from EPIC-InterAct; low fatty fish intake was found to interact with GADA positivity on the risk of adult onset diabetes (attributable proportion due to interaction [AP] 0.48, 95% CI 0.24-0.72), and findings were similar for plasma n-3 PUFA. In ESTRID, sweetened beverage intake was positively associated with both LADA and type 2 diabetes. For LADA, the increased risk was evident only among carriers of low/intermediate risk HLA genotypes (OR per one daily serving 1.32, 95% CI 1.06-1.64). BMI was suggested to only partly mediate the associations between sweetened beverages and risk of LADA and type 2 diabetes, indicating that there may also be direct effects on glucose homeostasis. These results suggest that long-chain n-3 PUFAs from fish may decrease the risk of LADA whereas intake of sweetened beverages may increase the risk. Importantly, these findings indicate that diet may be a modifiable lifestyle factor influencing the development of LADA and hence be a target for preventive strategies.
    • Subject Terms:
      Human Nutrition;Public Health
    • Subject Terms:
    • Accession Number:
      anthropometric measurements, drinks, polyunsaturated fatty acids, studies, dissertations
    • CABICODES:
      Nutrition Related Disorders and Therapeutic Nutrition (VV130)
      Non-communicable Human Diseases and Injuries (VV600)
      Aquatic Produce (QQ060)
    • Accession Number:
      56-86-0; 9004-10-8
    • Publication Information:
      Thesis; URL:https://openarchive.ki.se/xmlui/handle/10616/46673
    • Accession Number:
      20203185630
    • Copyright:
      ©2019 CAB International
  • Citations
    • ABNT:
      EDWALL LÖFVENBORG, J. Diet and the risk of latent autoimmune diabetes in adults (LADA) : studies on the association with fish and sweetened beverages. 2019. Karolinska Institutet, Stockholm; Sweden, 2019. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185630. Acesso em: 8 ago. 2020.
    • AMA:
      Edwall Löfvenborg J. Diet and the risk of latent autoimmune diabetes in adults (LADA) : studies on the association with fish and sweetened beverages. Diet and the risk of latent autoimmune diabetes in adults (LADA): studies on the association with fish and sweetened beverages. 2019:72. Accessed August 8, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185630
    • APA:
      Edwall Löfvenborg, J. (2019). Diet and the risk of latent autoimmune diabetes in adults (LADA) : studies on the association with fish and sweetened beverages [Karolinska Institutet]. In Diet and the risk of latent autoimmune diabetes in adults (LADA): studies on the association with fish and sweetened beverages (p. 72).
    • Chicago/Turabian: Author-Date:
      Edwall Löfvenborg, J. 2019. “Diet and the Risk of Latent Autoimmune Diabetes in Adults (LADA) : Studies on the Association with Fish and Sweetened Beverages.” Diet and the Risk of Latent Autoimmune Diabetes in Adults (LADA): Studies on the Association with Fish and Sweetened Beverages. Stockholm; Sweden: Karolinska Institutet. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185630.
    • Harvard:
      Edwall Löfvenborg, J. (2019) Diet and the risk of latent autoimmune diabetes in adults (LADA) : studies on the association with fish and sweetened beverages, Diet and the risk of latent autoimmune diabetes in adults (LADA): studies on the association with fish and sweetened beverages. Karolinska Institutet. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185630 (Accessed: 8 August 2020).
    • Harvard: Australian:
      Edwall Löfvenborg, J 2019, ‘Diet and the risk of latent autoimmune diabetes in adults (LADA) : studies on the association with fish and sweetened beverages’, Karolinska Institutet, Stockholm; Sweden, Diet and the risk of latent autoimmune diabetes in adults (LADA): studies on the association with fish and sweetened beverages, p. 72, viewed 8 August 2020, .
    • MLA:
      Edwall Löfvenborg, J. “Diet and the Risk of Latent Autoimmune Diabetes in Adults (LADA) : Studies on the Association with Fish and Sweetened Beverages.” Diet and the Risk of Latent Autoimmune Diabetes in Adults (LADA): Studies on the Association with Fish and Sweetened Beverages, Karolinska Institutet, 2019, p. 72. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185630.
    • Chicago/Turabian: Humanities:
      Edwall Löfvenborg, J. “Diet and the Risk of Latent Autoimmune Diabetes in Adults (LADA) : Studies on the Association with Fish and Sweetened Beverages.” Diet and the Risk of Latent Autoimmune Diabetes in Adults (LADA): Studies on the Association with Fish and Sweetened Beverages. Karolinska Institutet, 2019. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185630.
    • Vancouver/ICMJE:
      Edwall Löfvenborg J. Diet and the risk of latent autoimmune diabetes in adults (LADA) : studies on the association with fish and sweetened beverages [Internet]. Diet and the risk of latent autoimmune diabetes in adults (LADA): studies on the association with fish and sweetened beverages. [Stockholm; Sweden]: Karolinska Institutet; 2019 [cited 2020 Aug 8]. p. 72. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lhh&AN=20203185630