Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Stockton Press Country of Publication: England NLM ID: 9609749 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5624 (Electronic) Linking ISSN: 13624393 NLM ISO Abbreviation: Spinal Cord Subsets: PubMed not MEDLINE
    • Publication Information:
      Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1996-
    • Abstract:
      Study Design: Prospective, randomized and controlled study.
      Objectives: The aim of the study was to investigate the effect of intermittent normobaric hyperoxia (InHO) for treatment of neuropathic pain in patients with spinal cord injury (SCI).
      Setting: The First Affiliated Hospital of Nanhua University, Hengyang, Hunan Province, China.
      Methods: Patients with SCI from Hunan Province were recruited from the First Affiliated Hospital of Nanhua University. History, duration, localization and characteristics of pain were recorded. Visual analog scale (VAS), the Patient Global Impression of Change (PGIC) and Short Form-36 walk-wheel (SF-36ww) was used to investigate the effect of InHO. Patients were randomly assigned to study and control groups. In study group, patients were exposed to pure oxygen via non-rebreathing reservoir mask, which increased the provided oxygen at a rate of 7 l min -1 for 1 or 4 h daily in 2 weeks. While in control group, patients breathed air via non-rebreathing reservoir mask at the same rate.
      Results: A total of 62 SCI patients with neuropathic pain were included in the study. The mean age of the patients was 36.85±10.71 years. Out of 62 patients, 21 were tetraplegic and 41 were paraplegic. Overall, 14 patients had complete SCI while 48 patients had incomplete injuries. Three groups were similar with respect to age, gender, duration, smoker or not, level and severity of injury. In the 4 h per day InHO groups, a statistically significant reduction of the VAS values was observed (P<0.05). Significant difference was also found in SF-36ww pain scores and PGIC (P<0.05). However, such an effect was not evident in the control group.
      Conclusion: This study revealed that in treatment of neuropathic pain of SCI patients, InHO may be effective.
      Perspective: This article presents InHO may effectively complement pharmacological treatment in patients with SCI and neuropathic pain.
    • References:
      J Rehabil Res Dev. 2009;46(1):85-93. (PMID: 19533522)
      Anesth Analg. 2011 Sep;113(3):626-33. (PMID: 21596875)
      Spinal Cord. 2009 May;47(5):352-9. (PMID: 19002150)
      J Pain Symptom Manage. 2003 May;25(5 Suppl):S12-7. (PMID: 12694988)
      Curr Neurovasc Res. 2013 Feb;10(1):21-8. (PMID: 23151072)
      Cochrane Database Syst Rev. 2008 Jul 16;(3):CD005219. (PMID: 18646121)
      Nat Med. 2008 Mar;14(3):331-6. (PMID: 18264108)
      Eur J Neurol. 2006 Nov;13(11):1153-69. (PMID: 17038030)
      Am J Emerg Med. 2012 Nov;30(9):1760-4. (PMID: 22560101)
      Ann Phys Rehabil Med. 2009 Mar;52(2):149-66. (PMID: 19909705)
      Exp Neurol. 2013 Feb;240:9-16. (PMID: 23195595)
      Spinal Cord. 2001 May;39(5):256-62. (PMID: 11438841)
      J Neurochem. 2008 Dec;107(5):1196-205. (PMID: 18786175)
      Pain Res Manag. 2007 Spring;12(1):13-21. (PMID: 17372630)
      Eur J Pharmacol. 2009 Jun 2;611(1-3):22-9. (PMID: 19303405)
      J Stroke Cerebrovasc Dis. 2009 Sep-Oct;18(5):336-42. (PMID: 19717015)
      Eur J Pain. 2012 Sep;16(8):1094-105. (PMID: 22354664)
      Pharmacol Res. 2013 Aug;74:56-67. (PMID: 23732704)
      Spinal Cord. 2002 Jun;40(6):282-5. (PMID: 12037709)
      Spinal Cord. 2013 Apr;51(4):334-7. (PMID: 23295472)
      Pain. 2013 Sep;154(9):1778-82. (PMID: 23711481)
      J Spinal Cord Med. 2007;30(5):421-40. (PMID: 18092558)
      Brain Res. 2013 Nov 6;1537:111-6. (PMID: 23998986)
      J Neurochem. 2005 Dec;95(6):1689-703. (PMID: 16283857)
      J Mol Neurosci. 2014 Jun;53(2):251-61. (PMID: 24390961)
      Ann Phys Rehabil Med. 2009 Mar;52(2):83-102. (PMID: 19909700)
      Chang Gung Med J. 2005 Sep;28(9):597-605. (PMID: 16323550)
      Spinal Cord. 2009 Jan;47(1):50-5. (PMID: 18560375)
      Eur J Pain. 2010 Aug;14(7):670-81. (PMID: 20096614)
      Stroke. 2012 Jan;43(1):220-6. (PMID: 22020028)
      Pain. 2013 Nov;154(11):2469-76. (PMID: 23880056)
      JAMA. 2009 Dec 9;302(22):2451-7. (PMID: 19996400)
      Cell Mol Neurobiol. 2008 Dec;28(8):1049-56. (PMID: 18379870)
      Pain. 2010 Nov;151(2):296-306. (PMID: 20609516)
    • Publication Date:
      Date Created: 20141008 Latest Revision: 20191120
    • Publication Date:
      20201019
    • Accession Number:
      10.1038/sc.2014.161
    • Accession Number:
      25288038
  • Citations
    • ABNT:
      GUI, Y. et al. Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury. Spinal cord, [s. l.], v. 53, n. 3, p. 238–242, 2015. DOI 10.1038/sc.2014.161. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=25288038. Acesso em: 28 out. 2020.
    • AMA:
      Gui Y, Li H, Zhao M, Yang Q, Kuang X. Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury. Spinal cord. 2015;53(3):238-242. doi:10.1038/sc.2014.161
    • APA:
      Gui, Y., Li, H., Zhao, M., Yang, Q., & Kuang, X. (2015). Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury. Spinal Cord, 53(3), 238–242. https://doi.org/10.1038/sc.2014.161
    • Chicago/Turabian: Author-Date:
      Gui, Y, H Li, M Zhao, Q Yang, and X Kuang. 2015. “Effect of Intermittent Normobaric Hyperoxia for Treatment of Neuropathic Pain in Chinese Patients with Spinal Cord Injury.” Spinal Cord 53 (3): 238–42. doi:10.1038/sc.2014.161.
    • Harvard:
      Gui, Y. et al. (2015) ‘Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury’, Spinal cord, 53(3), pp. 238–242. doi: 10.1038/sc.2014.161.
    • Harvard: Australian:
      Gui, Y, Li, H, Zhao, M, Yang, Q & Kuang, X 2015, ‘Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury’, Spinal cord, vol. 53, no. 3, pp. 238–242, viewed 28 October 2020, .
    • MLA:
      Gui, Y., et al. “Effect of Intermittent Normobaric Hyperoxia for Treatment of Neuropathic Pain in Chinese Patients with Spinal Cord Injury.” Spinal Cord, vol. 53, no. 3, Mar. 2015, pp. 238–242. EBSCOhost, doi:10.1038/sc.2014.161.
    • Chicago/Turabian: Humanities:
      Gui, Y, H Li, M Zhao, Q Yang, and X Kuang. “Effect of Intermittent Normobaric Hyperoxia for Treatment of Neuropathic Pain in Chinese Patients with Spinal Cord Injury.” Spinal Cord 53, no. 3 (March 2015): 238–42. doi:10.1038/sc.2014.161.
    • Vancouver/ICMJE:
      Gui Y, Li H, Zhao M, Yang Q, Kuang X. Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury. Spinal cord [Internet]. 2015 Mar [cited 2020 Oct 28];53(3):238–42. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=25288038