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Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity.

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  • Additional Information
    • Source:
      Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Hindawi Pub. Co.
    • Subject Terms:
    • Abstract:
      Overweight and obesity are major threats to human health. Tea polyphenols exert multiple beneficial effects on human health and may play a positive regulatory role in fat assumption. However, how tea polyphenols contribute to the regulation of fat metabolism remains unclear to date. Small RNA expression profile can be regulated by tea polyphenols in adipocytes. Therefore, tea polyphenols may regulate fat metabolism by controlling small RNA-associated biological processes. In this study, we developed a systematic research platform based on mouse models and performed small RNA sequencing to identify the specific role of small RNAs in the regulatory effect of tea polyphenols on fat metabolism. We compared the expression levels of different small RNA subtypes, including piRNAs and miRNAs, and identified a group of differentially expressed small RNAs in the experimental and control groups. Most of these small RNAs participate in lipid metabolism, suggesting that small RNAs play a significant role in tea polyphenol-associated obesity and related pathogenesis. Furthermore, gene ontology and KEGG pathway enrichment indicated that small RNAs influence the regulatory effects of tea polyphenols on obesity, revealing the potential pathogenic mechanisms for such nutritional disease.
    • Accession Number:
      0 (Plant Extracts)
      0 (Polyphenols)
      0 (Tea)
    • Publication Date:
      Date Created: 20190718 Date Completed: 20191219 Latest Revision: 20191219
    • Publication Date:
      20200827
    • Accession Number:
      PMC6595166
    • Accession Number:
      10.1155/2019/2579734
    • Accession Number:
      31312655
  • Citations
    • ABNT:
      LI, Z. et al. Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity. BioMed research international, [s. l.], v. 2019, p. 2579734, 2019. DOI 10.1155/2019/2579734. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=31312655. Acesso em: 20 set. 2020.
    • AMA:
      Li Z, Liu Y, Zhao W, et al. Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity. BioMed research international. 2019;2019:2579734. doi:10.1155/2019/2579734
    • APA:
      Li, Z., Liu, Y., Zhao, W., Wu, X., Jiang, X., Yang, L., Xing, C., You, L., Song, J., & Li, H. (2019). Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity. BioMed Research International, 2019, 2579734. https://doi.org/10.1155/2019/2579734
    • Chicago/Turabian: Author-Date:
      Li, Zhandong, Yue Liu, Weihao Zhao, Xiuhua Wu, Xiujuan Jiang, Lili Yang, Chaoqun Xing, Lixin You, Jiwei Song, and Hao Li. 2019. “Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity.” BioMed Research International 2019 (June): 2579734. doi:10.1155/2019/2579734.
    • Harvard:
      Li, Z. et al. (2019) ‘Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity’, BioMed research international, 2019, p. 2579734. doi: 10.1155/2019/2579734.
    • Harvard: Australian:
      Li, Z, Liu, Y, Zhao, W, Wu, X, Jiang, X, Yang, L, Xing, C, You, L, Song, J & Li, H 2019, ‘Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity’, BioMed research international, vol. 2019, p. 2579734, viewed 20 September 2020, .
    • MLA:
      Li, Zhandong, et al. “Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity.” BioMed Research International, vol. 2019, June 2019, p. 2579734. EBSCOhost, doi:10.1155/2019/2579734.
    • Chicago/Turabian: Humanities:
      Li, Zhandong, Yue Liu, Weihao Zhao, Xiuhua Wu, Xiujuan Jiang, Lili Yang, Chaoqun Xing, Lixin You, Jiwei Song, and Hao Li. “Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity.” BioMed Research International 2019 (June 11, 2019): 2579734. doi:10.1155/2019/2579734.
    • Vancouver/ICMJE:
      Li Z, Liu Y, Zhao W, Wu X, Jiang X, Yang L, et al. Pathogenic Effects and Potential Regulatory Mechanisms of Tea Polyphenols on Obesity. BioMed research international [Internet]. 2019 Jun 11 [cited 2020 Sep 20];2019:2579734. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=31312655