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Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota.

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  • Additional Information
    • Source:
      Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Hindawi Pub. Co.
    • Subject Terms:
    • Abstract:
      Background: Changes in the gut microbiota are associated with cardiovascular disease progression. Xiao-Qing-Long Tang (XQLT), a traditional herbal formula, has an anti-inflammatory effect and regulates the steady state of the immune system, which is also associated with the progression of heart failure with preserved ejection faction (HFpEF). In this study, we investigated whether XQLT could contribute to prevent the development of HFpEF and whether the modulation of the gut microbiota by this herbal formula could be involved in such effect.
      Methods: The gut microbiota, SCFAs, the histology/function of the heart, and systolic blood pressure were examined to evaluate the effect of XQLT on the gut microbiota and the progression of HFpEF after oral administration of XQLT to model rats. Furthermore, we evaluated, through fecal microbiota transplantation experiments, whether the favorable effects of XQLT could be mediated by the gut microbiota.
      Results: Oral administration of XQLT contributed to the reduction of elevated blood pressure, inflammation, and compensatory hypertrophy, features that are associated with the progression of HFpEF. The gut microbiota composition, SCFA levels, and intestinal mucosal histology were improved after treatment with XQLT. Moreover, fecal transfer from XQLT-treated rats was sufficient to prevent the progression of HFpEF.
      Conclusions: These data suggested that XQLT prevented the development of HFpEF in model rats by regulating the composition of the gut microbiota.
    • Accession Number:
      0 (Drugs, Chinese Herbal)
      0 (sho-seiryu-to)
    • Publication Date:
      Date Created: 20190810 Date Completed: 20200115 Latest Revision: 20200115
    • Publication Date:
      20200827
    • Accession Number:
      PMC6668541
    • Accession Number:
      10.1155/2019/9637479
    • Accession Number:
      31396536
  • Citations
    • ABNT:
      ZHOU, G.-F. et al. Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota. BioMed research international, [s. l.], v. 2019, p. 9637479, 2019. DOI 10.1155/2019/9637479. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=31396536. Acesso em: 22 out. 2020.
    • AMA:
      Zhou G-F, Jiang Y-H, Ma D-F, et al. Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota. BioMed research international. 2019;2019:9637479. doi:10.1155/2019/9637479
    • APA:
      Zhou, G.-F., Jiang, Y.-H., Ma, D.-F., Wang, Y.-C., Yang, J.-L., Chen, J.-Y., Chi, C.-Y., Han, X.-W., Li, Z.-Y., & Li, X. (2019). Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota. BioMed Research International, 2019, 9637479. https://doi.org/10.1155/2019/9637479
    • Chicago/Turabian: Author-Date:
      Zhou, Guo-Feng, Yue-Hua Jiang, Du-Fang Ma, Yong-Cheng Wang, Jin-Long Yang, Ji-Ye Chen, Chen-Yu Chi, Xiao-Wei Han, Zhao-Yu Li, and Xiao Li. 2019. “Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota.” BioMed Research International 2019 (July): 9637479. doi:10.1155/2019/9637479.
    • Harvard:
      Zhou, G.-F. et al. (2019) ‘Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota’, BioMed research international, 2019, p. 9637479. doi: 10.1155/2019/9637479.
    • Harvard: Australian:
      Zhou, G-F, Jiang, Y-H, Ma, D-F, Wang, Y-C, Yang, J-L, Chen, J-Y, Chi, C-Y, Han, X-W, Li, Z-Y & Li, X 2019, ‘Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota’, BioMed research international, vol. 2019, p. 9637479, viewed 22 October 2020, .
    • MLA:
      Zhou, Guo-Feng, et al. “Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota.” BioMed Research International, vol. 2019, July 2019, p. 9637479. EBSCOhost, doi:10.1155/2019/9637479.
    • Chicago/Turabian: Humanities:
      Zhou, Guo-Feng, Yue-Hua Jiang, Du-Fang Ma, Yong-Cheng Wang, Jin-Long Yang, Ji-Ye Chen, Chen-Yu Chi, Xiao-Wei Han, Zhao-Yu Li, and Xiao Li. “Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota.” BioMed Research International 2019 (July 18, 2019): 9637479. doi:10.1155/2019/9637479.
    • Vancouver/ICMJE:
      Zhou G-F, Jiang Y-H, Ma D-F, Wang Y-C, Yang J-L, Chen J-Y, et al. Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota. BioMed research international [Internet]. 2019 Jul 18 [cited 2020 Oct 22];2019:9637479. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=31396536