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Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101202210 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-7364 (Electronic) Linking ISSN: 14739542 NLM ISO Abbreviation: Hum. Genomics Subsets: MEDLINE
    • Publication Information:
      Publication: 2012- : London : BioMed Central
      Original Publication: London : Henry Stewart Publications, c2003-
    • Subject Terms:
    • Abstract:
      Background: Long non-coding RNAs became the hot spots in the carcinogenesis of various tumors. This case-control study evaluated the association between the rs2151280 in lncRNA CDKN2B-AS1 and lung cancer risk.
      Methods: This study included 507 lung cancer patients and 542 healthy individuals. Odds ratios and their 95% confidence intervals were calculated by unconditional logistic regression analysis to evaluate the association between the rs2151280 and lung cancer risk.
      Results: Compared with individuals carrying TT genotype, individuals carrying CC genotype of rs2151280 had a decreased risk of lung cancer (OR = 0.640, 95%CI = 0.421-0.972, P = 0.036). In the recessive model, rs2151280 CC genotype was observed to reduce the risk of lung cancer (OR = 0.684). C allele was associated with non-small cell lung cancer risk (OR = 0.674). The rs2151280 was significantly associated with lung adenocarcinoma risk (CCvsTT: OR = 0.567, 95%CI = 0.333-0.965, P = 0.037; CCvsTC+TT: OR = 0.543, 95%CI 0.330-0.893, P = 0.016, respectively). However, there was no significant association between rs2151280 and lung squamous cell carcinoma risk in five models. The quantitative analysis suggested that there were no significant interactions of rs2151280 with smoking exposure to lung cancer susceptibility.
      Conclusions: This hospital-based case-control study suggested that CDKN2B-AS1 rs2151280 T>C was associated with the risk of lung cancer.
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    • Grant Information:
      81673261 International National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: Interaction*; Lung cancer*; Single nucleotide polymorphism*; lncRNA*
    • Accession Number:
      0 (ANRIL long non-coding RNA, human)
      0 (RNA, Long Noncoding)
    • Publication Date:
      Date Created: 20191129 Date Completed: 20200518 Latest Revision: 20200518
    • Publication Date:
      20200827
    • Accession Number:
      PMC6880550
    • Accession Number:
      10.1186/s40246-019-0240-4
    • Accession Number:
      31775885
  • Citations
    • ABNT:
      LV, X. et al. Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population. Human genomics, [s. l.], v. 13, n. 1, p. 58, 2019. DOI 10.1186/s40246-019-0240-4. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=31775885. Acesso em: 29 set. 2020.
    • AMA:
      Lv X, Cui Z, Li H, et al. Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population. Human genomics. 2019;13(1):58. doi:10.1186/s40246-019-0240-4
    • APA:
      Lv, X., Cui, Z., Li, H., Li, J., Yang, Z., Bi, Y., Gao, M., Zhang, Z., Wang, S., Zhou, B., & Yin, Z. (2019). Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population. Human Genomics, 13(1), 58. https://doi.org/10.1186/s40246-019-0240-4
    • Chicago/Turabian: Author-Date:
      Lv, Xiaoting, Zhigang Cui, Hang Li, Juan Li, Zitai Yang, Yanhong Bi, Min Gao, et al. 2019. “Association between Polymorphism in CDKN2B-AS1 Gene and Its Interaction with Smoking on the Risk of Lung Cancer in a Chinese Population.” Human Genomics 13 (1): 58. doi:10.1186/s40246-019-0240-4.
    • Harvard:
      Lv, X. et al. (2019) ‘Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population’, Human genomics, 13(1), p. 58. doi: 10.1186/s40246-019-0240-4.
    • Harvard: Australian:
      Lv, X, Cui, Z, Li, H, Li, J, Yang, Z, Bi, Y, Gao, M, Zhang, Z, Wang, S, Zhou, B & Yin, Z 2019, ‘Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population’, Human genomics, vol. 13, no. 1, p. 58, viewed 29 September 2020, .
    • MLA:
      Lv, Xiaoting, et al. “Association between Polymorphism in CDKN2B-AS1 Gene and Its Interaction with Smoking on the Risk of Lung Cancer in a Chinese Population.” Human Genomics, vol. 13, no. 1, Nov. 2019, p. 58. EBSCOhost, doi:10.1186/s40246-019-0240-4.
    • Chicago/Turabian: Humanities:
      Lv, Xiaoting, Zhigang Cui, Hang Li, Juan Li, Zitai Yang, Yanhong Bi, Min Gao, et al. “Association between Polymorphism in CDKN2B-AS1 Gene and Its Interaction with Smoking on the Risk of Lung Cancer in a Chinese Population.” Human Genomics 13, no. 1 (November 27, 2019): 58. doi:10.1186/s40246-019-0240-4.
    • Vancouver/ICMJE:
      Lv X, Cui Z, Li H, Li J, Yang Z, Bi Y, et al. Association between polymorphism in CDKN2B-AS1 gene and its interaction with smoking on the risk of lung cancer in a Chinese population. Human genomics [Internet]. 2019 Nov 27 [cited 2020 Sep 29];13(1):58. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdc&AN=31775885