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phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats.

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  • Author(s): Bifone, A.. Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy; Gozzi, A., ORCID Gozzi, A., ORCID 0000-0002-5731-4137. Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy; Cippitelli, A.. School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy; Matzeu, A.. Department of Molecular and Cellular Neuroscience, Scripps Research Institute, La Jolla, CA, US; Domi, E., ORCID Domi, E., ORCID 0000-0001-5726-4814. School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy; Li, H.. School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy; Scuppa, G.. Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy; Cannella, N., ORCID Cannella, N., ORCID 0000-0002-2891-8679. School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy; Ubaldi, M.. School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy; Weiss, F.. Department of Molecular and Cellular Neuroscience, Scripps Research Institute, La Jolla, CA, US; Ciccocioppo, R., ORCID 0000-0003-3126-9240. Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy, Ciccocioppo, R., ORCID 0000-0003-3126-9240. Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy,
  • Source:
    Addiction Biology, Vol 24(5), Sep, 2019. pp. 981-993.
  • Publisher:
    United Kingdom : Wiley-Blackwell Publishing Ltd.
  • Language:
    English
  • Document Type:
    Journal Article
  • Publication Type:
    Journal; Peer Reviewed Journal
  • Additional Information
    • Address:
      Ciccocioppo, R., School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032, Camerino, Italy, [email protected]
    • Source:
      Addict Biol
    • Physical Description:
      13
    • Other Publishers:
      United Kingdom : Taylor & Francis
    • ISSN:
      1355-6215 (Print)
      1369-1600 (Electronic)
    • Keywords:
      addiction, phMRI, reward
    • Abstract:
      Alcoholism is often associated with other forms of drug abuse, suggesting that innate predisposing factors may confer vulnerability to addiction to diverse substances. However, the neurobiological bases of these factors remain unknown. Here, we have used a combination of imaging, neurochemistry and behavioral techniques to investigate responses to the psychostimulant amphetamine in Marchigian Sardinian (msP) alcohol‐preferring rats, a model of vulnerability to alcoholism. Specifically, we employed pharmacological magnetic resonance imaging to investigate the neural circuits engaged by amphetamine challenge, and to relate functional reactivity to neurochemical and behavioral responses. Moreover, we studied self‐administration of cocaine in the msP rats. We found stronger functional responses in the extended amygdala, alongside with increased release of dopamine in the nucleus accumbens shell and augmented vertical locomotor activity compared with controls. Wistar and msP rats did not differ in operant cocaine self‐administration under short access (2 hours) conditions, but msP rats exhibited a higher propensity to escalate drug intake following long access (6 hours). Our findings suggest that neurobiological and genetic mechanisms that convey vulnerability to excessive alcohol drinking also facilitate the transition from psychostimulants use to abuse. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
    • Subject Terms:
    • Subject Terms:
      Alcoholism; Amphetamine; Amygdala; Animals; Brain; Central Nervous System Stimulants; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Functional Neuroimaging; Glutamic Acid; Locomotion; Magnetic Resonance Imaging; Microdialysis; Nucleus Accumbens; Rats; Self Administration; gamma-Aminobutyric Acid
    • PsycINFO Classification:
      Psychopharmacology (2580)
    • Population:
      Animal
      Male
    • Grant Sponsorship:
      Sponsor: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, US
      Grant Number: AA014351
      Recipients: Weiss, F.; Ciccocioppo, R.

      Sponsor: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, US
      Grant Number: AA017447
      Other Details: MR
      Recipients: Ciccocioppo, R.
    • Methodology:
      Empirical Study; Quantitative Study
    • Physical Description:
      Electronic
    • Publication Date:
      20181018
    • Publication Date:
      20200903
    • Copyright:
      Society for the Study of Addiction. 2018
    • Accession Number:
      http://dx.doi.org/10.1111/adb.12671
    • Accession Number:
      30328656
    • Accession Number:
      2018-52530-001
  • Citations
    • ABNT:
      BIFONE, A. et al. phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats. Addiction Biology, [s. l.], v. 24, n. 5, p. 981–993, 2019. DOI 10.1111/adb.12671. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2018-52530-001. Acesso em: 22 out. 2020.
    • AMA:
      Bifone A, Gozzi A, Cippitelli A, et al. phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats. Addiction Biology. 2019;24(5):981-993. doi:10.1111/adb.12671
    • APA:
      Bifone, A., Gozzi, A., Cippitelli, A., Matzeu, A., Domi, E., Li, H., Scuppa, G., Cannella, N., Ubaldi, M., Weiss, F., & Ciccocioppo, R. (2019). phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats. Addiction Biology, 24(5), 981–993. https://doi.org/10.1111/adb.12671
    • Chicago/Turabian: Author-Date:
      Bifone, A., A. Gozzi, A. Cippitelli, A. Matzeu, E. Domi, H. Li, G. Scuppa, et al. 2019. “PhMRI, Neurochemical and Behavioral Responses to Psychostimulants Distinguishing Genetically Selected Alcohol‐preferring from Genetically Heterogenous Rats.” Addiction Biology 24 (5): 981–93. doi:10.1111/adb.12671.
    • Harvard:
      Bifone, A. et al. (2019) ‘phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats’, Addiction Biology, 24(5), pp. 981–993. doi: 10.1111/adb.12671.
    • Harvard: Australian:
      Bifone, A, Gozzi, A, Cippitelli, A, Matzeu, A, Domi, E, Li, H, Scuppa, G, Cannella, N, Ubaldi, M, Weiss, F & Ciccocioppo, R 2019, ‘phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats’, Addiction Biology, vol. 24, no. 5, pp. 981–993, viewed 22 October 2020, .
    • MLA:
      Bifone, A., et al. “PhMRI, Neurochemical and Behavioral Responses to Psychostimulants Distinguishing Genetically Selected Alcohol‐preferring from Genetically Heterogenous Rats.” Addiction Biology, vol. 24, no. 5, Sept. 2019, pp. 981–993. EBSCOhost, doi:10.1111/adb.12671.
    • Chicago/Turabian: Humanities:
      Bifone, A., A. Gozzi, A. Cippitelli, A. Matzeu, E. Domi, H. Li, G. Scuppa, et al. “PhMRI, Neurochemical and Behavioral Responses to Psychostimulants Distinguishing Genetically Selected Alcohol‐preferring from Genetically Heterogenous Rats.” Addiction Biology 24, no. 5 (September 2019): 981–93. doi:10.1111/adb.12671.
    • Vancouver/ICMJE:
      Bifone A, Gozzi A, Cippitelli A, Matzeu A, Domi E, Li H, et al. phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol‐preferring from genetically heterogenous rats. Addiction Biology [Internet]. 2019 Sep [cited 2020 Oct 22];24(5):981–93. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2018-52530-001