Structural neuroimaging in anorexia nervosa: Cortical surface architecture and white matter microstructure in acute and remitted patients, their unaffected sisters, and unrelated healthy controls.

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  • Author(s): Miles, Amy E.. University of Toronto (Canada), Medical Science, Canada
  • Source:
    Dissertation Abstracts International: Section B: The Sciences and Engineering, Vol 80(4-B)(E), 2019.
  • Publisher:
    US : ProQuest Information & Learning
  • Language:
    English
  • Document Type:
    Dissertation
  • Publication Type:
    Dissertation Abstract
  • Additional Information
    • Other Journal Titles:
      Dissertation Abstracts International
    • ISSN:
      0419-4217 (Print)
    • ISBN:
      978-0438684324
    • Keywords:
      structural neuroimaging, anorexia nervosa, white matter, remitted patients
    • Abstract:
      Background: Anorexia nervosa (AN) is a heritable psychiatric disorder characterized by starvation and emaciation. Although AN is widely considered a brain-based disease, its neuroanatomical correlates are poorly understood. As such, we aim to characterize cortical surface architecture and white matter microstructure in acute and remitted patients (acAN, recAN), their unaffected sisters (sibAN), and unrelated healthy controls (HC). Methods: Neuroimaging and assessment data was collected from 84 women (24 acAN, 24 recAN, 12 sibAN, 24 HC). T1/diffusion-weighted MRI data was acquired on a 3T GE scanner with 60 gradient directions, and it was processed with Freesurfer and FSL pipelines. Group differences in vertex/voxel-wise cortical thickness (CT), cortical surface area (CSA), local gyrification index (LGI), fractional anisotropy (FA), and mean diffusivity (MD) were tested with separate univariate analyses of covariance. Relationships among vertex/voxel-wise CT, CSA, FA, and MD and empirical measures of clinical and cognitive impairment were tested with separate linear regressions. Results: We detected significant group differences in CT in frontal and temporal regions (acAN < recAN, HC), LGI in frontal and frontoparietal regions (recAN < acAN, HC; acAN HC). We also detected significant associations between CSA in frontotemporal regions and an index of psychosocial impairment (r = -0.617) and FA in major white matter tracts and an index of cognitive impairment (r = -0.561). Conclusions: Site-specific cortical thinning and hypogyrification appear state-dependent and starvation-driven, and we propose cellular remodeling as a mechanism of action. Site-specific dysgyrification and white matter impairment appear trait-based and developmental in origin, and we propose atypical cortical expansion, altered myelination, and systemic inflammation as mechanisms of action. Variations in cortical surface architecture and white matter microstructure in regions subserving affective and cognitive processing could contribute to AN vulnerability and manifestation. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
    • Dissertation Details:
      UMI Order Number: AAI10937369
      OpenURL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10937369
      Advisor(s): Allan S. Kaplan
      Degree: Ph.D., 2018
      Institution: University of Toronto (Canada)
      Department: Medical Science
    • Subject Terms:
    • PsycINFO Classification:
      Physiological Psychology & Neuroscience (2500)
    • Population:
      Human
      Female
    • Methodology:
      Brain Imaging; Empirical Study; Quantitative Study
    • Physical Description:
      Electronic
    • Publication Date:
      20190304
    • Accession Number:
      2019-00352-153
  • Citations
    • ABNT:
      MILES, A. E. Structural neuroimaging in anorexia nervosa: Cortical surface architecture and white matter microstructure in acute and remitted patients, their unaffected sisters, and unrelated healthy controls. 2019. ProQuest Information & Learning, [s. l.], 2019. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2019-00352-153. Acesso em: 25 fev. 2020.
    • AMA:
      Miles AE. Structural neuroimaging in anorexia nervosa: Cortical surface architecture and white matter microstructure in acute and remitted patients, their unaffected sisters, and unrelated healthy controls. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2019;80(4-B(E)). http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2019-00352-153. Accessed February 25, 2020.
    • APA:
      Miles, A. E. (2019). Structural neuroimaging in anorexia nervosa: Cortical surface architecture and white matter microstructure in acute and remitted patients, their unaffected sisters, and unrelated healthy controls [ProQuest Information & Learning]. In Dissertation Abstracts International: Section B: The Sciences and Engineering (Vol. 80, Issue 4–B(E)).
    • Chicago/Turabian: Author-Date:
      Miles, Amy E. 2019. “Structural Neuroimaging in Anorexia Nervosa: Cortical Surface Architecture and White Matter Microstructure in Acute and Remitted Patients, Their Unaffected Sisters, and Unrelated Healthy Controls.” Dissertation Abstracts International: Section B: The Sciences and Engineering. ProQuest Information & Learning. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2019-00352-153.
    • Harvard:
      Miles, A. E. (2019) Structural neuroimaging in anorexia nervosa: Cortical surface architecture and white matter microstructure in acute and remitted patients, their unaffected sisters, and unrelated healthy controls, Dissertation Abstracts International: Section B: The Sciences and Engineering. ProQuest Information & Learning. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2019-00352-153 (Accessed: 25 February 2020).
    • Harvard: Australian:
      Miles, AE 2019, ‘Structural neuroimaging in anorexia nervosa: Cortical surface architecture and white matter microstructure in acute and remitted patients, their unaffected sisters, and unrelated healthy controls’, ProQuest Information & Learning, Dissertation Abstracts International: Section B: The Sciences and Engineering, vol. 80, no. 4–B(E), viewed 25 February 2020, .
    • MLA:
      Miles, Amy E. “Structural Neuroimaging in Anorexia Nervosa: Cortical Surface Architecture and White Matter Microstructure in Acute and Remitted Patients, Their Unaffected Sisters, and Unrelated Healthy Controls.” Dissertation Abstracts International: Section B: The Sciences and Engineering, vol. 80, no. 4–B(E), ProQuest Information & Learning, 2019. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2019-00352-153.
    • Chicago/Turabian: Humanities:
      Miles, Amy E. “Structural Neuroimaging in Anorexia Nervosa: Cortical Surface Architecture and White Matter Microstructure in Acute and Remitted Patients, Their Unaffected Sisters, and Unrelated Healthy Controls.” Dissertation Abstracts International: Section B: The Sciences and Engineering. ProQuest Information & Learning, 2019. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2019-00352-153.
    • Vancouver/ICMJE:
      Miles AE. Structural neuroimaging in anorexia nervosa: Cortical surface architecture and white matter microstructure in acute and remitted patients, their unaffected sisters, and unrelated healthy controls [Internet]. Vol. 80, Dissertation Abstracts International: Section B: The Sciences and Engineering. ProQuest Information & Learning; 2019 [cited 2020 Feb 25]. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2019-00352-153