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The functional role of the anterior insular cortex in cognitive control.

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  • Author(s): Chen, Yu. City University of New York, Psychology, US
  • Source:
    Dissertation Abstracts International: Section B: The Sciences and Engineering, Vol 81(10-B), 2020.
  • Publisher:
    US : ProQuest Information & Learning
  • Language:
    English
  • Document Type:
    Dissertation
  • Publication Type:
    Dissertation Abstract
  • Additional Information
    • Other Journal Titles:
      Dissertation Abstracts International
    • ISSN:
      0419-4217 (Print)
    • ISBN:
      979-8607319038
    • Keywords:
      functional role, anterior insular cortex, cognitive control, goal-directed behaviors
    • Abstract:
      Cognitive control, a higher level psychological construct, refers to efficient coordination of thoughts and actions for the accomplishment of goal-directed behaviors. Cognitive control is supported by a commonly activated cognitive control network, and the anterior insular cortex (AIC) serves as one of its key structures. However, the functional role of the AIC in cognitive control has not been fully understood. A human lesion study was conducted to examine the necessary function of the AIC in cognitive control. A mouse optogenetic study with fiber photometry recording further examined whether the bilateral AIC was important for cognitive control and how the AIC played a role in different stages of cognitive control (e.g., state uncertainty processing, execution of control, or motor generation). Compatible versions of the post-target interference task consisting of congruent and incongruent conditions were used to measure cognitive control in humans and mice, respectively. In the human lesion study, the patients with lesions in the AIC showed longer overall response time (RT), lower overall processing efficiency, and greater conflict effects of RT and processing efficiency. These findings provided lesion-based evidence to support a causally necessary function of the AIC in cognitive control. In the mouse study, the accuracy of the congruent condition decreased when the AIC was silenced unilaterally or bilaterally by optogenetics after the cue sound and when the AIC was silenced bilaterally during the presentation of target and distractor stimuli, indicating that the disruption of the AIC resulted in a reduction in global processing efficiency. The fiber photometry results showed a significant decrease of the calcium-dependent signal after the cue sound compared to baseline, suggesting that the AIC was involved in state uncertainty processing. The results of the human lesion study identified the necessary role of the AIC in cognitive control. The findings of the mouse study further demonstrated the role of the AIC in cognitive control in both hemispheres and suggested a critical role of the AIC in state uncertainty processing. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
    • Dissertation Details:
      UMI Order Number: AAI27832094
      OpenURL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:27832094
      Advisor(s): Fan, Jin
      Degree: Ph.D., 2020
      Institution: City University of New York
      Department: Psychology
    • Subject Terms:
    • PsycINFO Classification:
      Physiological Psychology & Neuroscience (2500)
    • Population:
      Human
    • Methodology:
      Empirical Study; Quantitative Study
    • Physical Description:
      Electronic
    • Publication Date:
      20200629
    • Accession Number:
      2020-31777-001
  • Citations
    • ABNT:
      CHEN, Y. The functional role of the anterior insular cortex in cognitive control. 2020. ProQuest Information & Learning, [s. l.], 2020. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2020-31777-001. Acesso em: 4 dez. 2020.
    • AMA:
      Chen Y. The functional role of the anterior insular cortex in cognitive control. Dissertation Abstracts International: Section B: The Sciences and Engineering. 2020;81(10-B). Accessed December 4, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2020-31777-001
    • APA:
      Chen, Y. (2020). The functional role of the anterior insular cortex in cognitive control [ProQuest Information & Learning]. In Dissertation Abstracts International: Section B: The Sciences and Engineering (Vol. 81, Issue 10–B).
    • Chicago/Turabian: Author-Date:
      Chen, Yu. 2020. “The Functional Role of the Anterior Insular Cortex in Cognitive Control.” Dissertation Abstracts International: Section B: The Sciences and Engineering. ProQuest Information & Learning. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2020-31777-001.
    • Harvard:
      Chen, Y. (2020) The functional role of the anterior insular cortex in cognitive control, Dissertation Abstracts International: Section B: The Sciences and Engineering. ProQuest Information & Learning. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2020-31777-001 (Accessed: 4 December 2020).
    • Harvard: Australian:
      Chen, Y 2020, ‘The functional role of the anterior insular cortex in cognitive control’, ProQuest Information & Learning, Dissertation Abstracts International: Section B: The Sciences and Engineering, vol. 81, no. 10–B, viewed 4 December 2020, .
    • MLA:
      Chen, Yu. “The Functional Role of the Anterior Insular Cortex in Cognitive Control.” Dissertation Abstracts International: Section B: The Sciences and Engineering, vol. 81, no. 10–B, ProQuest Information & Learning, 2020. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2020-31777-001.
    • Chicago/Turabian: Humanities:
      Chen, Yu. “The Functional Role of the Anterior Insular Cortex in Cognitive Control.” Dissertation Abstracts International: Section B: The Sciences and Engineering. ProQuest Information & Learning, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2020-31777-001.
    • Vancouver/ICMJE:
      Chen Y. The functional role of the anterior insular cortex in cognitive control [Internet]. Vol. 81, Dissertation Abstracts International: Section B: The Sciences and Engineering. ProQuest Information & Learning; 2020 [cited 2020 Dec 4]. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=psyh&AN=2020-31777-001