Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Human facial allotransplantation: a 2-year follow-up study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Affiliation:
      Institute of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
    • Online Access: Dubernard JM, Devauchelle B. Face transplantation. (LANCET) 8/23/2008; 372 (9639): 603-604 <span>(105649535)</span>
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      BACKGROUND: Progress in composite tissue allotransplantation could provide a new treatment for patients with severe facial disfigurements. We did a partial facial allotransplantation in 2006, and report here the 2 year follow-up of the patient. METHODS: The recipient, a 30-year-old man from China, had his face severely injured by a bear in October, 2004. Allograft composite tissue transplantation was done in April, 2006, after careful systemic preparation. The surgery included anastomosis of the right mandibular artery and anterior facial vein, whole repair of total nose, upper lip, parotid gland, front wall of the maxillary sinus, part of the infraorbital wall, and zygomatic bone. Facial nerve anastomosis was done during the surgery. Quadruple immunomodulatory therapy was used, containing tacrolimus, mycophenolate mofetil, corticosteroids, and humanised IL-2 receptor monoclonal antibody. Follow-up included T lymphocyte subgroups in peripheral blood, pathological and immunohistochemical examinations, functional progress, and psychological support. FINDINGS: Composite tissue flap survived well. There were three acute rejection episodes at 3, 5, and 17 months after transplantation, but these were controlled by adjustment of the tacrolimus dose or the application of methylprednisolone pulse therapy. Hepatic and renal functions were normal, and there was no infection. The patient developed hyperglycaemia on day 3 after transplantation, which was controlled by medication. INTERPRETATION: Facial transplantation could be successful in the short term, but the procedure was not without complications. However, promising results could mean that this procedure might be an option for long-term restoration of severe facial disfigurement.
    • Journal Subset:
      Biomedical; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed; UK & Ireland
    • ISSN:
      0099-5355
    • MEDLINE Info:
      PMID: NLM18722867 NLM UID: 2985213R
    • Publication Date:
      20080919
    • Publication Date:
      20200619
    • DOI:
      10.1016/s0140-6736(08)61276-3
    • Accession Number:
      105649556
  • Citations
    • ABNT:
      GUO S et al. Human facial allotransplantation: a 2-year follow-up study. Lancet, [s. l.], v. 372 North American Edition, n. 9639, p. 631–638, 2008. DOI 10.1016/s0140-6736(08)61276-3. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=105649556. Acesso em: 26 set. 2020.
    • AMA:
      Guo S, Han Y, Zhang X, et al. Human facial allotransplantation: a 2-year follow-up study. Lancet. 2008;372 North American Edition(9639):631-638. doi:10.1016/s0140-6736(08)61276-3
    • APA:
      Guo S, Han Y, Zhang X, Lu B, Yi C, Zhang H, Ma X, Wang D, Yang L, Fan X, Liu Y, Lu K, & Li H. (2008). Human facial allotransplantation: a 2-year follow-up study. Lancet, 372 North American Edition(9639), 631–638. https://doi.org/10.1016/s0140-6736(08)61276-3
    • Chicago/Turabian: Author-Date:
      Guo S, Han Y, Zhang X, Lu B, Yi C, Zhang H, Ma X, et al. 2008. “Human Facial Allotransplantation: A 2-Year Follow-up Study.” Lancet 372 North American Edition (9639): 631–38. doi:10.1016/s0140-6736(08)61276-3.
    • Harvard:
      Guo S et al. (2008) ‘Human facial allotransplantation: a 2-year follow-up study’, Lancet, 372 North American Edition(9639), pp. 631–638. doi: 10.1016/s0140-6736(08)61276-3.
    • Harvard: Australian:
      Guo S, Han Y, Zhang X, Lu B, Yi C, Zhang H, Ma X, Wang D, Yang L, Fan X, Liu Y, Lu K & Li H 2008, ‘Human facial allotransplantation: a 2-year follow-up study’, Lancet, vol. 372 North American Edition, no. 9639, pp. 631–638, viewed 26 September 2020, .
    • MLA:
      Guo S, et al. “Human Facial Allotransplantation: A 2-Year Follow-up Study.” Lancet, vol. 372 North American Edition, no. 9639, Aug. 2008, pp. 631–638. EBSCOhost, doi:10.1016/s0140-6736(08)61276-3.
    • Chicago/Turabian: Humanities:
      Guo S, Han Y, Zhang X, Lu B, Yi C, Zhang H, Ma X, et al. “Human Facial Allotransplantation: A 2-Year Follow-up Study.” Lancet 372 North American Edition, no. 9639 (August 23, 2008): 631–38. doi:10.1016/s0140-6736(08)61276-3.
    • Vancouver/ICMJE:
      Guo S, Han Y, Zhang X, Lu B, Yi C, Zhang H, et al. Human facial allotransplantation: a 2-year follow-up study. Lancet [Internet]. 2008 Aug 23 [cited 2020 Sep 26];372 North American Edition(9639):631–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=105649556