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Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents.

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  • Additional Information
    • Affiliation:
      Department of Medical Imaging, E‐Da Hospital, Kaohsiung
      School of Medicine for International Students, I‐Shou University, Kaohsiung
      Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
      Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei
      Institute of Environmental Health, China Medical University College of Public Health, Taichung
      National Research Institute of Chinese Medicine, Ministry of Health and Welfare
      Institute of Hospital and Health Care Administration, National Yang‐Ming University, Taipei
      Chia Nan University of Pharmacy and Science, Tainan
      Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei Taiwan, ROC
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Aim: To investigate the appropriate fasting plasma glucose threshold by which to define prediabetes in children and adolescents, based on its ability to predict incident paediatric diabetes. Methods: In a nationwide survey of diabetes and renal disease conducted between 1992 and 2000 in all school‐aged children in Taiwan, those with abnormal results in repeated urine tests received further physical examination and blood tests. Students who had blood tests for at least two time points were selected for the present study (N = 12 119). The incidence of paediatric diabetes, adjusted hazard ratio and predictive power of fasting plasma glucose were analysed. Results: The incidence of paediatric diabetes increased with increasing fasting plasma glucose levels. Groups with fasting plasma glucose >5.6 mmol/l had a higher adjusted hazard ratio. The adjusted hazard ratio of incident diabetes for participants with higher fasting plasma glucose rose continuously when using a higher threshold for fasting plasma glucose. The area under the receiver‐operating characteristic curve for fasting plasma glucose was 0.628 for predicting paediatric diabetes. The association between fasting plasma glucose and incident paediatric diabetes and the area under the receiver‐operating characteristic curve were similar in boys and girls and were higher in the age group 12–18 years. According to receiver‐operating characteristic curve analysis, the optimal thresholds, sensitivity and specificity were 4.75 mmol/l, 65% and 51%, respectively, for those aged 6–11 years and 5.19 mmol/l, 60% and 73%, respectively, for those aged 12–18 years. Conclusion: Fasting plasma glucose is associated with the incidence of paediatric diabetes. The results of the present study can be used as reference data to suggest a cut‐off value to define paediatric prediabetes. What's new?: This is one of the few studies to investigate the plasma glucose threshold to predict incident paediatric diabetes.Using a nationwide dataset, we found that fasting plasma glucose (FPG) level was associated with the incidence of paediatric diabetes.The predictive power of FPG is better in the age group 12–18 years than in the age group 6–11 years.The results of the present study can be used as reference data to suggest a cut‐off value of FPG for paediatric prediabetes.
    • Journal Subset:
      Biomedical; Europe; Peer Reviewed; UK & Ireland
    • ISSN:
      0742-3071
    • MEDLINE Info:
      NLM UID: 8500858
    • Publication Date:
      20190417
    • Publication Date:
      20200430
    • DOI:
      http://dx.doi.org/10.1111/dme.13925
    • Accession Number:
      135876863
  • Citations
    • ABNT:
      YANG, C. ‐Y. et al. Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents. Diabetic Medicine, [s. l.], v. 36, n. 5, p. 633–643, 2019. DOI 10.1111/dme.13925. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=135876863. Acesso em: 22 set. 2020.
    • AMA:
      Yang C ‐Y., Li H ‐Y., Sung F ‐C., Tan EC, Wei J ‐N., Chuang L ‐M. Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents. Diabetic Medicine. 2019;36(5):633-643. doi:10.1111/dme.13925
    • APA:
      Yang, C. ‐Y., Li, H. ‐Y., Sung, F. ‐C., Tan, E. C., Wei, J. ‐N., & Chuang, L. ‐M. (2019). Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents. Diabetic Medicine, 36(5), 633–643. https://doi.org/10.1111/dme.13925
    • Chicago/Turabian: Author-Date:
      Yang, C.‐Y., H.‐Y. Li, F.‐C. Sung, E. Chia‐Hui Tan, J.‐N. Wei, and L.‐M. Chuang. 2019. “Relationship between Fasting Plasma Glucose and Incidence of Diabetes in Children and Adolescents.” Diabetic Medicine 36 (5): 633–43. doi:10.1111/dme.13925.
    • Harvard:
      Yang, C. ‐Y. et al. (2019) ‘Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents’, Diabetic Medicine, 36(5), pp. 633–643. doi: 10.1111/dme.13925.
    • Harvard: Australian:
      Yang, C ‐Y., Li, H ‐Y., Sung, F ‐C., Tan, EC, Wei, J ‐N. & Chuang, L ‐M. 2019, ‘Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents’, Diabetic Medicine, vol. 36, no. 5, pp. 633–643, viewed 22 September 2020, .
    • MLA:
      Yang, C.‐Y., et al. “Relationship between Fasting Plasma Glucose and Incidence of Diabetes in Children and Adolescents.” Diabetic Medicine, vol. 36, no. 5, May 2019, pp. 633–643. EBSCOhost, doi:10.1111/dme.13925.
    • Chicago/Turabian: Humanities:
      Yang, C.‐Y., H.‐Y. Li, F.‐C. Sung, E. Chia‐Hui Tan, J.‐N. Wei, and L.‐M. Chuang. “Relationship between Fasting Plasma Glucose and Incidence of Diabetes in Children and Adolescents.” Diabetic Medicine 36, no. 5 (May 2019): 633–43. doi:10.1111/dme.13925.
    • Vancouver/ICMJE:
      Yang C ‐Y., Li H ‐Y., Sung F ‐C., Tan EC, Wei J ‐N., Chuang L ‐M. Relationship between fasting plasma glucose and incidence of diabetes in children and adolescents. Diabetic Medicine [Internet]. 2019 May [cited 2020 Sep 22];36(5):633–43. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=135876863