Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Affiliation:
      The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China
      Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      T cells and dendritic cells (DCs) that are positive for the tissue-resident marker CD103 play a vital role in antitumor immunity. In this study, multiplexed immunohistochemistry was applied to stain CD103 and the T-cell marker CD8 as well as the DC marker CD11c on formalin-fixed, paraffin-embedded oral squamous cell carcinoma (OSCC) tissues. Then, the density of CD103+CD8+ and CD103+CD11c+ tumor-infiltrating lymphocytes (TILs) in the intratumoral and stromal regions was calculated, and the correlation of CD103+CD8+ TIL and CD103+CD11c+ TIL density with OSCC patient prognosis was analyzed. The results revealed that CD103+CD8+ TILs and CD103+CD11c+ TILs were abundant in the stromal region and that increased stromal CD103+CD8+ TIL and intratumoral CD103+CD11c+ TIL density indicated a favorable prognosis. Moreover, we freshly isolated TILs from OSCC samples and performed flow cytometry to verify that CD103+CD8+ TILs display a tissue-resident memory T-cell (Trm) phenotype, and we discriminated CD103+CD11c+ TILs from tumor-associated macrophages.
    • Journal Subset:
      Biomedical; Blind Peer Reviewed; Expert Peer Reviewed; Peer Reviewed; USA
    • ISSN:
      0022-0345
    • MEDLINE Info:
      PMID: NLM31658426 NLM UID: 0354343
    • Publication Date:
      20200520
    • Publication Date:
      20200726
    • DOI:
      10.1177/0022034519882618
    • Accession Number:
      139788871
  • Citations
    • ABNT:
      XIAO, Y. et al. CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer. Journal of Dental Research, [s. l.], v. 98, n. 13, p. 1480–1487, 2019. DOI 10.1177/0022034519882618. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=139788871. Acesso em: 26 set. 2020.
    • AMA:
      Xiao Y, Li H, Mao L, et al. CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer. Journal of Dental Research. 2019;98(13):1480-1487. doi:10.1177/0022034519882618
    • APA:
      Xiao, Y., Li, H., Mao, L., Yang, Q. C., Fu, L. Q., Wu, C. C., Liu, B., & Sun, Z. J. (2019). CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer. Journal of Dental Research, 98(13), 1480–1487. https://doi.org/10.1177/0022034519882618
    • Chicago/Turabian: Author-Date:
      Xiao, Y., H. Li, L. Mao, Q.C. Yang, L.Q. Fu, C.C. Wu, B. Liu, and Z.J. Sun. 2019. “CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer.” Journal of Dental Research 98 (13): 1480–87. doi:10.1177/0022034519882618.
    • Harvard:
      Xiao, Y. et al. (2019) ‘CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer’, Journal of Dental Research, 98(13), pp. 1480–1487. doi: 10.1177/0022034519882618.
    • Harvard: Australian:
      Xiao, Y, Li, H, Mao, L, Yang, QC, Fu, LQ, Wu, CC, Liu, B & Sun, ZJ 2019, ‘CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer’, Journal of Dental Research, vol. 98, no. 13, pp. 1480–1487, viewed 26 September 2020, .
    • MLA:
      Xiao, Y., et al. “CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer.” Journal of Dental Research, vol. 98, no. 13, Dec. 2019, pp. 1480–1487. EBSCOhost, doi:10.1177/0022034519882618.
    • Chicago/Turabian: Humanities:
      Xiao, Y., H. Li, L. Mao, Q.C. Yang, L.Q. Fu, C.C. Wu, B. Liu, and Z.J. Sun. “CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer.” Journal of Dental Research 98, no. 13 (December 2019): 1480–87. doi:10.1177/0022034519882618.
    • Vancouver/ICMJE:
      Xiao Y, Li H, Mao L, Yang QC, Fu LQ, Wu CC, et al. CD103+ T and Dendritic Cells Indicate a Favorable Prognosis in Oral Cancer. Journal of Dental Research [Internet]. 2019 Dec [cited 2020 Sep 26];98(13):1480–7. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=rzh&AN=139788871